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- W2613736410 endingPage "346" @default.
- W2613736410 startingPage "336" @default.
- W2613736410 abstract "Pancreatic ductal adenocarcinoma (PDAC) driver genes may be altered simultaneously as well as sequentially. Four major mutational processes act on the PDAC genome. Several genomic and transcriptomic subtypes of PDAC have been proposed. PDAC primaries and metastases have both genomic and epigenomic differences. Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest epithelial malignancies. Improvements in our understanding of PDAC carcinogenesis will hopefully improve its detection, management, and outcomes, as has been achieved with other malignancies. Here we review the literature on the natural history of PDAC, including its cell of origin, the initiating somatic mutational events, pathways deranged in the mature tumor, its biological heterogeneity, and the relationship of the primary tumor with metastases. We also suggest areas for further research and highlight translatable findings that are beginning to make clinical inroads. Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest epithelial malignancies. Improvements in our understanding of PDAC carcinogenesis will hopefully improve its detection, management, and outcomes, as has been achieved with other malignancies. Here we review the literature on the natural history of PDAC, including its cell of origin, the initiating somatic mutational events, pathways deranged in the mature tumor, its biological heterogeneity, and the relationship of the primary tumor with metastases. We also suggest areas for further research and highlight translatable findings that are beginning to make clinical inroads." @default.
- W2613736410 created "2017-05-19" @default.
- W2613736410 creator A5012881959 @default.
- W2613736410 creator A5016377624 @default.
- W2613736410 creator A5077898047 @default.
- W2613736410 date "2017-05-01" @default.
- W2613736410 modified "2023-10-17" @default.
- W2613736410 title "Molecular Events in the Natural History of Pancreatic Cancer" @default.
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