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• W2613844594 abstract "Purpose To perform a critical analysis on the impact of depth of response in newly diagnosed multiple myeloma (MM). Patients and Methods Data were analyzed from 609 patients who were enrolled in the GEM (Grupo Español de Mieloma) 2000 and GEM2005MENOS65 studies for transplant-eligible MM and the GEM2010MAS65 clinical trial for elderly patients with MM who had minimal residual disease (MRD) assessments 9 months after study enrollment. Median follow-up of the series was 71 months. Results Achievement of complete remission (CR) in the absence of MRD negativity was not associated with prolonged progression-free survival (PFS) and overall survival (OS) compared with near-CR or partial response (median PFS, 27, 27, and 29 months, respectively; median OS, 59, 64, and 65 months, respectively). MRD-negative status was strongly associated with prolonged PFS (median, 63 months; P < .001) and OS (median not reached; P < .001) overall and in subgroups defined by prior transplantation, disease stage, and cytogenetics, with prognostic superiority of MRD negativity versus CR particularly evident in patients with high-risk cytogenetics. Accordingly, Harrell C statistics showed higher discrimination for both PFS and OS in Cox models that included MRD (as opposed to CR) for response assessment. Superior MRD-negative rates after different induction regimens anticipated prolonged PFS. Among 34 MRD-negative patients with MM and a phenotypic pattern of bone marrow involvement similar to monoclonal gammopathy of undetermined significance at diagnosis, the probability of “operational cure” was high; median PFS was 12 years, and the 10-year OS rate was 94%. Conclusion Our results demonstrate that MRD-negative status surpasses the prognostic value of CR achievement for PFS and OS across the disease spectrum, regardless of the type of treatment or patient risk group. MRD negativity should be considered as one of the most relevant end points for transplant-eligible and elderly fit patients with MM." @default.
• W2613844594 created "2017-05-19" @default.
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• W2613844594 date "2017-09-01" @default.
• W2613844594 modified "2023-10-18" @default.
• W2613844594 title "Depth of Response in Multiple Myeloma: A Pooled Analysis of Three PETHEMA/GEM Clinical Trials" @default.
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• W2613844594 cites W2022227828 @default.
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• W2613844594 cites W2028150271 @default.
• W2613844594 cites W2028286166 @default.
• W2613844594 cites W2039496823 @default.
• W2613844594 cites W2044436186 @default.
• W2613844594 cites W2044799988 @default.
• W2613844594 cites W2048483323 @default.
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• W2613844594 cites W2097690999 @default.
• W2613844594 cites W2108485762 @default.
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• W2613844594 cites W2129104200 @default.
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• W2613844594 cites W2141014263 @default.
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• W2613844594 cites W2144588669 @default.
• W2613844594 cites W2144728882 @default.
• W2613844594 cites W2146909892 @default.
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• W2613844594 cites W2150254829 @default.
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• W2613844594 cites W2185344664 @default.
• W2613844594 cites W2209833625 @default.
• W2613844594 cites W2221325899 @default.
• W2613844594 cites W2319764074 @default.
• W2613844594 cites W2344906871 @default.
• W2613844594 cites W2345005763 @default.
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• W2613844594 doi "https://doi.org/10.1200/jco.2016.69.2517" @default.
• W2613844594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5568033" @default.
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• W2613844594 hasPublicationYear "2017" @default.
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