FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2613847425> ?p ?o ?g. }

• W2613847425 endingPage "3857" @default.
• W2613847425 startingPage "3848" @default.
• W2613847425 abstract "Bile acids and epithelial-derived human β-defensins (HβDs) are known to be important factors in the regulation of colonic mucosal barrier function and inflammation. We hypothesized that bile acids regulate colonic HβD expression and aimed to test this by investigating the effects of deoxycholic acid (DCA) and ursodeoxycholic acid on the expression and release of HβD1 and HβD2 from colonic epithelial cells and mucosal tissues. DCA (10–150 μM) stimulated the release of both HβD1 and HβD2 from epithelial cell monolayers and human colonic mucosal tissue in vitro. In contrast, ursodeoxycholic acid (50–200 μM) inhibited both basal and DCA-induced defensin release. Effects of DCA were mimicked by the Takeda GPCR 5 agonist, INT-777 (50 μM), but not by the farnesoid X receptor agonist, GW4064 (10 μM). INT-777 also stimulated colonic HβD1 and HβD2 release from wild-type, but not Takeda GPCR 5−/−, mice. DCA stimulated phosphorylation of the p65 subunit of NF-κB, an effect that was attenuated by ursodeoxycholic acid, whereas an NF-κB inhibitor, BMS-345541 (25 μM), inhibited DCA-induced HβD2, but not HβD1, release. We conclude that bile acids can differentially regulate colonic epithelial HβD expression and secretion and discuss the implications of our findings for intestinal health and disease.—Lajczak, N. K., Saint-Criq, V., O’Dwyer, A. M., Perino, A., Adorini, L., Schoonjans, K., Keely, S. J. Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human β-defensin-1 and -2 secretion by colonic epithelial cells. FASEB J. 31, 3848–3857 (2017). www.fasebj.org—Lajczak, Natalia K., Saint-Criq, Vinciane, O’Dwyer, Aoife M., Perino, Alessia, Adorini, Luciano, Schoonjans, Kristina, Keely, Stephen J. Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human β-defensin-1 and -2 secretion by colonic epithelial cells. FASEB J. 31, 3848–3857 (2017)" @default.
• W2613847425 created "2017-05-19" @default.
• W2613847425 creator A5033554852 @default.
• W2613847425 creator A5050589305 @default.
• W2613847425 creator A5058458204 @default.
• W2613847425 creator A5068868147 @default.
• W2613847425 creator A5082832136 @default.
• W2613847425 creator A5087268653 @default.
• W2613847425 creator A5091787800 @default.
• W2613847425 date "2017-09-01" @default.
• W2613847425 modified "2023-10-01" @default.
• W2613847425 title "Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human β‐defensin‐1 and ‐2 secretion by colonic epithelial cells" @default.
• W2613847425 cites W1529695053 @default.
• W2613847425 cites W1555526329 @default.
• W2613847425 cites W1625660792 @default.
• W2613847425 cites W1914953479 @default.
• W2613847425 cites W1964509264 @default.
• W2613847425 cites W1967056255 @default.
• W2613847425 cites W1967283548 @default.
• W2613847425 cites W1969516822 @default.
• W2613847425 cites W1970832390 @default.
• W2613847425 cites W1971253831 @default.
• W2613847425 cites W1972672220 @default.
• W2613847425 cites W1975858613 @default.
• W2613847425 cites W1977160855 @default.
• W2613847425 cites W1989172856 @default.
• W2613847425 cites W1995715825 @default.
• W2613847425 cites W1997929840 @default.
• W2613847425 cites W2000335726 @default.
• W2613847425 cites W2017422805 @default.
• W2613847425 cites W2017929099 @default.
• W2613847425 cites W2018308755 @default.
• W2613847425 cites W2027987416 @default.
• W2613847425 cites W2049506766 @default.
• W2613847425 cites W2054646626 @default.
• W2613847425 cites W2066607937 @default.
• W2613847425 cites W2066684479 @default.
• W2613847425 cites W2067255647 @default.
• W2613847425 cites W2070950782 @default.
• W2613847425 cites W2077960502 @default.
• W2613847425 cites W2079903421 @default.
• W2613847425 cites W2081271380 @default.
• W2613847425 cites W2083096979 @default.
• W2613847425 cites W2088068912 @default.
• W2613847425 cites W2094948602 @default.
• W2613847425 cites W2100757511 @default.
• W2613847425 cites W2104159258 @default.
• W2613847425 cites W2104518375 @default.
• W2613847425 cites W2105013832 @default.
• W2613847425 cites W2119573240 @default.
• W2613847425 cites W2122734862 @default.
• W2613847425 cites W2124723056 @default.
• W2613847425 cites W2125386218 @default.
• W2613847425 cites W2125524268 @default.
• W2613847425 cites W2130896556 @default.
• W2613847425 cites W2141435682 @default.
• W2613847425 cites W2141444445 @default.
• W2613847425 cites W2149814742 @default.
• W2613847425 cites W2152714616 @default.
• W2613847425 cites W2154780633 @default.
• W2613847425 cites W2186320679 @default.
• W2613847425 cites W2191241037 @default.
• W2613847425 cites W2335470694 @default.
• W2613847425 cites W2466472759 @default.
• W2613847425 cites W2488768059 @default.
• W2613847425 cites W2546339689 @default.
• W2613847425 doi "https://doi.org/10.1096/fj.201601365r" @default.
• W2613847425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28487283" @default.
• W2613847425 hasPublicationYear "2017" @default.
• W2613847425 type Work @default.
• W2613847425 sameAs 2613847425 @default.
• W2613847425 citedByCount "18" @default.
• W2613847425 countsByYear W26138474252018 @default.
• W2613847425 countsByYear W26138474252019 @default.
• W2613847425 countsByYear W26138474252020 @default.
• W2613847425 countsByYear W26138474252021 @default.
• W2613847425 countsByYear W26138474252022 @default.
• W2613847425 countsByYear W26138474252023 @default.
• W2613847425 crossrefType "journal-article" @default.
• W2613847425 hasAuthorship W2613847425A5033554852 @default.
• W2613847425 hasAuthorship W2613847425A5050589305 @default.
• W2613847425 hasAuthorship W2613847425A5058458204 @default.
• W2613847425 hasAuthorship W2613847425A5068868147 @default.
• W2613847425 hasAuthorship W2613847425A5082832136 @default.
• W2613847425 hasAuthorship W2613847425A5087268653 @default.
• W2613847425 hasAuthorship W2613847425A5091787800 @default.
• W2613847425 hasConcept C104317684 @default.
• W2613847425 hasConcept C126322002 @default.
• W2613847425 hasConcept C134018914 @default.
• W2613847425 hasConcept C170493617 @default.
• W2613847425 hasConcept C185592680 @default.
• W2613847425 hasConcept C203862802 @default.
• W2613847425 hasConcept C2778938600 @default.
• W2613847425 hasConcept C2779399885 @default.
• W2613847425 hasConcept C2780749602 @default.
• W2613847425 hasConcept C2780965833 @default.
• W2613847425 hasConcept C39321552 @default.
• W2613847425 hasConcept C49039625 @default.

• next