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• W2613894174 abstract "Many traditional treatments have been recommended in the alternative medicine for treatment of diabetes mellitus. Juniperprocera is one ofthe known hypoglycemic agents, which is used in[olklori medicineforimproving blood glucose control and preventing long term complications in diabetes mellitus. This study was carried out to clarify the role ofJuniper on the histological structure ofislets ofLangerhans. In this study, twentyjive adult male albino rats were used. Diabetes mellitus was inducedin 20 rats, using IP injection of180 mglkg body weight (EW) of alloxan. The diabetic rats were dividedinto four groups, three ofwhich were fed on a diet containing 2.5%, 5% and 7.5% BWofJuniperus procera for 6 weeks. The fourtlt group (positive control) received an ordinary diet. Another jive lion-diabetic rats reserved as (negative control group), who received neither alloxan nor the mentionedplant. Followingconsumptionofplants, blood glucose was measuredevery day andon the last day ofthe experimentserum insulin was measured. Serial sections of the pancreas were prepared and stained with H&E, Masson trichrome and immunohistochemicalstaining ofp-cells by anti-insulin antibody. Morphology ofthe pancreatic sections and the following morphometricparameters: Density {area %) ofanti-insulin antibody reaction in islets, percent ofP cells and the average area of the islets in whole pancreas were studied. The quantitative results were tabulated andstatistically analyzed. The microscopicalresults ofdiabetic group showedmarkeddegenerative changes ofcells mostly in centers ofislets with insulinitis: The condensationofconnectivetissue aroundislets was evident. Also, there was markeddecrease in p-cellpopulation a/islets. The previously described effect ofalloxan on the beta cell was · not reversed completely by usingjuniper. Meanwhile, there waspartial recovery to signs ofinflammation in islets and aroundacini. The previously mentionedmorphometricparametersdetected no statistical significantchange between juniper treated and untreated diabetics. In conclusion,juniper has a hypoglycemiceffect hut this is not through the improvementofp-cells structure." @default.
• W2613894174 created "2017-05-19" @default.
• W2613894174 creator A5007554523 @default.
• W2613894174 date "2006-01-01" @default.
• W2613894174 modified "2023-09-26" @default.
• W2613894174 title "EFFECT OF JUNIPER ON THE STRUCTUREOF ISLETS OF LANGERHANSIN ALLOXAN-INDUCEDDIABETIC RATS: HISTOLOGICALAND IMM,UNOHISTOCHEMICALSTUDY" @default.
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