Matches in SemOpenAlex for { <https://semopenalex.org/work/W2613903695> ?p ?o ?g. }
- W2613903695 endingPage "49501" @default.
- W2613903695 startingPage "49484" @default.
- W2613903695 abstract "Angiogenesis is a coordinated process tightly regulated by the balance between Delta-like-4 (DLL4) and Jagged-1 (JAG1) in endothelial cells. Here we show that galectin-3 (gal-3), a glycan-binding protein secreted by cancer cells under hypoxic conditions, triggers sprouting angiogenesis, assisted by hypoxic changes in the glycosylation status of endothelial cells that enhance binding to gal-3. Galectin-3's proangiogenic functions were found to be predominantly dependent on the Notch ligand JAG1. Differential direct binding to JAG1 was shown by surface plasmon resonance assay. Upon binding to Notch ligands, gal-3 preferentially increased JAG1 protein half-life over DLL4 and preferentially activated JAG1/Notch-1 signaling in endothelial cells. JAG1 overexpression in Lewis lung carcinoma cells accelerated tumor growth in vivo, but this effect was prevented in Lgals3-/- mice. Our findings establish gal-3 as a molecular regulator of the JAG1/Notch-1 signaling pathway and have direct implications for the development of strategies aimed at controlling tumor angiogenesis." @default.
- W2613903695 created "2017-05-19" @default.
- W2613903695 creator A5011876389 @default.
- W2613903695 creator A5015466957 @default.
- W2613903695 creator A5023518824 @default.
- W2613903695 creator A5051348893 @default.
- W2613903695 creator A5067434604 @default.
- W2613903695 creator A5079633934 @default.
- W2613903695 creator A5081447773 @default.
- W2613903695 creator A5090152669 @default.
- W2613903695 date "2017-05-09" @default.
- W2613903695 modified "2023-10-14" @default.
- W2613903695 title "Galectin-3 acts as an angiogenic switch to induce tumor angiogenesis via Jagged-1/Notch activation" @default.
- W2613903695 cites W1519008651 @default.
- W2613903695 cites W1583391226 @default.
- W2613903695 cites W1598905390 @default.
- W2613903695 cites W1599406214 @default.
- W2613903695 cites W1976022047 @default.
- W2613903695 cites W1980333945 @default.
- W2613903695 cites W1982246723 @default.
- W2613903695 cites W1982571513 @default.
- W2613903695 cites W1984439708 @default.
- W2613903695 cites W1986963456 @default.
- W2613903695 cites W1990607537 @default.
- W2613903695 cites W1993363047 @default.
- W2613903695 cites W1996168249 @default.
- W2613903695 cites W2005276971 @default.
- W2613903695 cites W2006122359 @default.
- W2613903695 cites W2006714159 @default.
- W2613903695 cites W2007431130 @default.
- W2613903695 cites W2012230649 @default.
- W2613903695 cites W2013557040 @default.
- W2613903695 cites W2016569548 @default.
- W2613903695 cites W2029642204 @default.
- W2613903695 cites W2029987331 @default.
- W2613903695 cites W2034458870 @default.
- W2613903695 cites W2040775078 @default.
- W2613903695 cites W2051319925 @default.
- W2613903695 cites W2057305568 @default.
- W2613903695 cites W2060638322 @default.
- W2613903695 cites W2062240872 @default.
- W2613903695 cites W2073551059 @default.
- W2613903695 cites W2075773133 @default.
- W2613903695 cites W2076274098 @default.
- W2613903695 cites W2079291777 @default.
- W2613903695 cites W2084152213 @default.
- W2613903695 cites W2097177355 @default.
- W2613903695 cites W2103046899 @default.
- W2613903695 cites W2105238396 @default.
- W2613903695 cites W2105471059 @default.
- W2613903695 cites W2115809606 @default.
- W2613903695 cites W2116396800 @default.
- W2613903695 cites W2121459017 @default.
- W2613903695 cites W2124396025 @default.
- W2613903695 cites W2129096575 @default.
- W2613903695 cites W2133750440 @default.
- W2613903695 cites W2134443544 @default.
- W2613903695 cites W2140925040 @default.
- W2613903695 cites W2147298899 @default.
- W2613903695 cites W2148102207 @default.
- W2613903695 cites W2151867536 @default.
- W2613903695 cites W2153726848 @default.
- W2613903695 cites W2156622694 @default.
- W2613903695 cites W2157172418 @default.
- W2613903695 cites W2157930949 @default.
- W2613903695 cites W2159166873 @default.
- W2613903695 cites W2166720212 @default.
- W2613903695 cites W2170642749 @default.
- W2613903695 cites W2244595585 @default.
- W2613903695 cites W2471339379 @default.
- W2613903695 cites W2504255207 @default.
- W2613903695 cites W2513771344 @default.
- W2613903695 cites W2549404431 @default.
- W2613903695 doi "https://doi.org/10.18632/oncotarget.17718" @default.
- W2613903695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5564783" @default.
- W2613903695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28533486" @default.
- W2613903695 hasPublicationYear "2017" @default.
- W2613903695 type Work @default.
- W2613903695 sameAs 2613903695 @default.
- W2613903695 citedByCount "56" @default.
- W2613903695 countsByYear W26139036952017 @default.
- W2613903695 countsByYear W26139036952018 @default.
- W2613903695 countsByYear W26139036952019 @default.
- W2613903695 countsByYear W26139036952020 @default.
- W2613903695 countsByYear W26139036952021 @default.
- W2613903695 countsByYear W26139036952022 @default.
- W2613903695 countsByYear W26139036952023 @default.
- W2613903695 crossrefType "journal-article" @default.
- W2613903695 hasAuthorship W2613903695A5011876389 @default.
- W2613903695 hasAuthorship W2613903695A5015466957 @default.
- W2613903695 hasAuthorship W2613903695A5023518824 @default.
- W2613903695 hasAuthorship W2613903695A5051348893 @default.
- W2613903695 hasAuthorship W2613903695A5067434604 @default.
- W2613903695 hasAuthorship W2613903695A5079633934 @default.
- W2613903695 hasAuthorship W2613903695A5081447773 @default.
- W2613903695 hasAuthorship W2613903695A5090152669 @default.
- W2613903695 hasBestOaLocation W26139036951 @default.
- W2613903695 hasConcept C134018914 @default.