Matches in SemOpenAlex for { <https://semopenalex.org/work/W2613911880> ?p ?o ?g. }
- W2613911880 abstract "Hsp70 participates in a broad spectrum of protein folding processes extending from nascent chain folding to protein disaggregation. This versatility in function is achieved through a diverse family of J-protein cochaperones that select substrates for Hsp70. Substrate selection is further tuned by transient complexation between different classes of J-proteins, which expands the range of protein aggregates targeted by metazoan Hsp70 for disaggregation. We assessed the prevalence and evolutionary conservation of J-protein complexation and cooperation in disaggregation. We find the emergence of a eukaryote-specific signature for interclass complexation of canonical J-proteins. Consistently, complexes exist in yeast and human cells, but not in bacteria, and correlate with cooperative action in disaggregation in vitro. Signature alterations exclude some J-proteins from networking, which ensures correct J-protein pairing, functional network integrity and J-protein specialization. This fundamental change in J-protein biology during the prokaryote-to-eukaryote transition allows for increased fine-tuning and broadening of Hsp70 function in eukaryotes." @default.
- W2613911880 created "2017-05-19" @default.
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- W2613911880 date "2017-05-15" @default.
- W2613911880 modified "2023-09-30" @default.
- W2613911880 title "Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes" @default.
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- W2613911880 cites W1661929959 @default.
- W2613911880 cites W1892595424 @default.
- W2613911880 cites W1925607018 @default.
- W2613911880 cites W1970094256 @default.
- W2613911880 cites W1972121275 @default.
- W2613911880 cites W1972980743 @default.
- W2613911880 cites W1981681091 @default.
- W2613911880 cites W1983897184 @default.
- W2613911880 cites W1992496728 @default.
- W2613911880 cites W1993161825 @default.
- W2613911880 cites W1995924392 @default.
- W2613911880 cites W1996114974 @default.
- W2613911880 cites W1999815303 @default.
- W2613911880 cites W2000891480 @default.
- W2613911880 cites W2008217034 @default.
- W2613911880 cites W2008545402 @default.
- W2613911880 cites W2011407729 @default.
- W2613911880 cites W2013453206 @default.
- W2613911880 cites W2013504083 @default.
- W2613911880 cites W2019012009 @default.
- W2613911880 cites W2022245842 @default.
- W2613911880 cites W2024243591 @default.
- W2613911880 cites W2028380145 @default.
- W2613911880 cites W2032625890 @default.
- W2613911880 cites W2035672439 @default.
- W2613911880 cites W2036604732 @default.
- W2613911880 cites W2048108076 @default.
- W2613911880 cites W2050196930 @default.
- W2613911880 cites W2051381895 @default.
- W2613911880 cites W2051884335 @default.
- W2613911880 cites W2052588595 @default.
- W2613911880 cites W2054646881 @default.
- W2613911880 cites W2055748044 @default.
- W2613911880 cites W2055926450 @default.
- W2613911880 cites W2058872839 @default.
- W2613911880 cites W2059277971 @default.
- W2613911880 cites W2061659241 @default.
- W2613911880 cites W2064878094 @default.
- W2613911880 cites W2071465766 @default.
- W2613911880 cites W2072475098 @default.
- W2613911880 cites W2077983593 @default.
- W2613911880 cites W2080988165 @default.
- W2613911880 cites W2082363738 @default.
- W2613911880 cites W2087903802 @default.
- W2613911880 cites W2092340914 @default.
- W2613911880 cites W2097566127 @default.
- W2613911880 cites W2098953186 @default.
- W2613911880 cites W2100758361 @default.
- W2613911880 cites W2103589432 @default.
- W2613911880 cites W2107867854 @default.
- W2613911880 cites W2109735813 @default.
- W2613911880 cites W2109936231 @default.
- W2613911880 cites W2120836664 @default.
- W2613911880 cites W2125465720 @default.
- W2613911880 cites W2127774996 @default.
- W2613911880 cites W2129434797 @default.
- W2613911880 cites W2130684289 @default.
- W2613911880 cites W2132717858 @default.
- W2613911880 cites W2135621733 @default.
- W2613911880 cites W2135880722 @default.
- W2613911880 cites W2137566700 @default.
- W2613911880 cites W2138472699 @default.
- W2613911880 cites W2138886850 @default.
- W2613911880 cites W2139544412 @default.
- W2613911880 cites W2140437023 @default.
- W2613911880 cites W2141052558 @default.
- W2613911880 cites W2149525061 @default.
- W2613911880 cites W2156160283 @default.
- W2613911880 cites W2158534684 @default.
- W2613911880 cites W2158703410 @default.
- W2613911880 cites W2166647921 @default.
- W2613911880 cites W2169478909 @default.
- W2613911880 cites W2170696006 @default.
- W2613911880 cites W2214677303 @default.
- W2613911880 cites W2277983104 @default.
- W2613911880 cites W2344278936 @default.
- W2613911880 cites W2597221181 @default.
- W2613911880 cites W3102606559 @default.
- W2613911880 doi "https://doi.org/10.7554/elife.24560" @default.
- W2613911880 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5542770" @default.
- W2613911880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28504929" @default.
- W2613911880 hasPublicationYear "2017" @default.
- W2613911880 type Work @default.