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- W2613950069 abstract "Hypertrophic cardiomyopathy (HCM) is primarily caused by mutations in β-cardiac myosin and myosin-binding protein-C (MyBP-C). Changes in the contractile parameters of myosin measured so far do not explain the clinical hypercontractility caused by such mutations. We propose that hypercontractility is due to an increase in the number of myosin heads (S1) that are accessible for force production. In support of this hypothesis, we demonstrate myosin tail (S2)-dependent functional regulation of actin-activated human β-cardiac myosin ATPase. In addition, we show that both S2 and MyBP-C bind to S1 and that phosphorylation of either S1 or MyBP-C weakens these interactions. Importantly, the S1-S2 interaction is also weakened by four myosin HCM-causing mutations but not by two other mutations. To explain these experimental results, we propose a working structural model involving multiple interactions, including those with myosin's own S2 and MyBP-C, that hold myosin in a sequestered state." @default.
- W2613950069 created "2017-05-19" @default.
- W2613950069 creator A5004015424 @default.
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- W2613950069 creator A5077117832 @default.
- W2613950069 date "2017-05-08" @default.
- W2613950069 modified "2023-10-13" @default.
- W2613950069 title "The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations" @default.
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- W2613950069 doi "https://doi.org/10.1038/nsmb.3408" @default.
- W2613950069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5737966" @default.
- W2613950069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28481356" @default.