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- W2613955154 abstract "Synthesis of a series of novel iminophosphorane der ivatives of Zidovudine (AZT) was accomplished through Staudinger reaction. In the first step PBr 3 was reacted with various substituted phenolic and a mino compounds in the presence of triethylamine (TEA) in dry tetrahydrofuran (THF) under nitrogen atmosphere followed by cyclisation of (±) 2-aminomethyl piperi dine, afforded diazaphosphole P(III) intermediates ( 3a- l).They were further reacted with zidovudine to obta in iminophosphorane derivatives 4a-l. They showed promising antioxidant activitiy. Their antioxidant activitiy was greatly influenced by the presence of different bio-active groups at phosphorus." @default.
- W2613955154 created "2017-05-19" @default.
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- W2613955154 date "2010-01-01" @default.
- W2613955154 modified "2023-09-23" @default.
- W2613955154 title "SYNTHESIS AND BIOLOGICAL ACTIVITY OF DIAZAPHOSPHOLO- IMINOPHOSPHORANE DERIVATIVES OF ZIDOVUDINE (AZT) THROUGH" @default.
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