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• W2613976768 abstract "The two-hybrid system is an incarnation of the split protein assay. Two-hybrid assays are usually carried out in vivo, but modifications are possible in vitro. The technique is used to detect interactions between two proteins where the proteins may or may not belong to the same organism. Two-hybrid assays were originally developed in yeast, but principally they should work in any other eukaryotes. To enable use in bacterial systems, various modifications have been made to the assay by using different split proteins, different types of reporters and different plasmids. Two-hybrid assays have applications in drug discovery, microbiology, molecular biology and virtually any other study of protein function.Key Concepts Split protein assays are typically developed from multidomain proteins, which makes their splitting easier and more predictable.Split protein assays make use of proteins that can be split and reconstituted non-covalently.Two-hybrid assays can be implemented in bacteria, in eukaryotes or in vitro.Two-hybrid assays can be used to detect interactions between proteins from distantly related organisms.Protein–protein interactions can be applied to biomarker discovery, to find drug targets, to determining functions of proteins with unknown function, protein–RNA interactions or even protein–small molecule interactions.Keywords:protein–protein interactions;protein domains;protein function;split protein assay;protein–RNA interaction;drug targets" @default.
• W2613976768 created "2017-05-19" @default.
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• W2613976768 date "2017-05-15" @default.
• W2613976768 modified "2023-09-25" @default.
• W2613976768 title "Two-Hybrid and Related Systems" @default.
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• W2613976768 doi "https://doi.org/10.1002/9780470015902.a0000981.pub2" @default.
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