Matches in SemOpenAlex for { <https://semopenalex.org/work/W2613988040> ?p ?o ?g. }
- W2613988040 endingPage "3745" @default.
- W2613988040 startingPage "3736" @default.
- W2613988040 abstract "Serine racemase (SRR) is an enzyme that produces d-serine from l-serine. d-Serine acts as an endogenous coagonist of NMDA-type glutamate receptors (NMDARs), which regulate many physiological functions. Over-activation of NMDARs induces excitotoxicity, which is observed in many neurodegenerative disorders and epilepsy states. In our previous works on the generation of SRR gene knockout (Srr-KO) mice and its protective effects against NMDA- and Aβ peptide-induced neurodegeneration, we hypothesized that the regulation of NMDARs’ over-activation by inhibition of SRR activity is one such therapeutic strategy to combat these disease states. In the previous study, we performed in silico screening to identify four compounds with inhibitory activities against recombinant SRR. Here, we synthesized 21 derivatives of candidate 1, one of four hit compounds, and performed screening by in vitro evaluations. The derivative 13J showed a significantly lower IC50 value in vitro, and suppressed neuronal over-activation in vivo." @default.
- W2613988040 created "2017-05-19" @default.
- W2613988040 creator A5001999219 @default.
- W2613988040 creator A5004389476 @default.
- W2613988040 creator A5006686399 @default.
- W2613988040 creator A5011533166 @default.
- W2613988040 creator A5017708258 @default.
- W2613988040 creator A5018218558 @default.
- W2613988040 creator A5025161323 @default.
- W2613988040 creator A5046801753 @default.
- W2613988040 creator A5050127204 @default.
- W2613988040 creator A5062206534 @default.
- W2613988040 creator A5080341740 @default.
- W2613988040 creator A5086236227 @default.
- W2613988040 date "2017-07-01" @default.
- W2613988040 modified "2023-10-03" @default.
- W2613988040 title "A novel serine racemase inhibitor suppresses neuronal over-activation in vivo" @default.
- W2613988040 cites W1541346279 @default.
- W2613988040 cites W1975580333 @default.
- W2613988040 cites W1977529115 @default.
- W2613988040 cites W1982634981 @default.
- W2613988040 cites W1983312542 @default.
- W2613988040 cites W1986002339 @default.
- W2613988040 cites W1986629750 @default.
- W2613988040 cites W1991615162 @default.
- W2613988040 cites W2005090869 @default.
- W2613988040 cites W2016571530 @default.
- W2613988040 cites W2017412107 @default.
- W2613988040 cites W2021222610 @default.
- W2613988040 cites W2042834556 @default.
- W2613988040 cites W2046909406 @default.
- W2613988040 cites W2048181000 @default.
- W2613988040 cites W2049511526 @default.
- W2613988040 cites W2049820669 @default.
- W2613988040 cites W2063331957 @default.
- W2613988040 cites W2074683128 @default.
- W2613988040 cites W2076730065 @default.
- W2613988040 cites W2077359599 @default.
- W2613988040 cites W2079179429 @default.
- W2613988040 cites W2089771154 @default.
- W2613988040 cites W2096285566 @default.
- W2613988040 cites W2110787178 @default.
- W2613988040 cites W2110954017 @default.
- W2613988040 cites W2143553520 @default.
- W2613988040 cites W2161648039 @default.
- W2613988040 cites W2162591320 @default.
- W2613988040 cites W2321219463 @default.
- W2613988040 cites W2325030053 @default.
- W2613988040 cites W2582426056 @default.
- W2613988040 doi "https://doi.org/10.1016/j.bmc.2017.05.011" @default.
- W2613988040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28533113" @default.
- W2613988040 hasPublicationYear "2017" @default.
- W2613988040 type Work @default.
- W2613988040 sameAs 2613988040 @default.
- W2613988040 citedByCount "13" @default.
- W2613988040 countsByYear W26139880402018 @default.
- W2613988040 countsByYear W26139880402019 @default.
- W2613988040 countsByYear W26139880402020 @default.
- W2613988040 countsByYear W26139880402021 @default.
- W2613988040 countsByYear W26139880402022 @default.
- W2613988040 countsByYear W26139880402023 @default.
- W2613988040 crossrefType "journal-article" @default.
- W2613988040 hasAuthorship W2613988040A5001999219 @default.
- W2613988040 hasAuthorship W2613988040A5004389476 @default.
- W2613988040 hasAuthorship W2613988040A5006686399 @default.
- W2613988040 hasAuthorship W2613988040A5011533166 @default.
- W2613988040 hasAuthorship W2613988040A5017708258 @default.
- W2613988040 hasAuthorship W2613988040A5018218558 @default.
- W2613988040 hasAuthorship W2613988040A5025161323 @default.
- W2613988040 hasAuthorship W2613988040A5046801753 @default.
- W2613988040 hasAuthorship W2613988040A5050127204 @default.
- W2613988040 hasAuthorship W2613988040A5062206534 @default.
- W2613988040 hasAuthorship W2613988040A5080341740 @default.
- W2613988040 hasAuthorship W2613988040A5086236227 @default.
- W2613988040 hasConcept C126322002 @default.
- W2613988040 hasConcept C150903083 @default.
- W2613988040 hasConcept C169760540 @default.
- W2613988040 hasConcept C170493617 @default.
- W2613988040 hasConcept C181199279 @default.
- W2613988040 hasConcept C185592680 @default.
- W2613988040 hasConcept C202751555 @default.
- W2613988040 hasConcept C207001950 @default.
- W2613988040 hasConcept C25498285 @default.
- W2613988040 hasConcept C2776414213 @default.
- W2613988040 hasConcept C2776925932 @default.
- W2613988040 hasConcept C2779134260 @default.
- W2613988040 hasConcept C2781012912 @default.
- W2613988040 hasConcept C55493867 @default.
- W2613988040 hasConcept C61174792 @default.
- W2613988040 hasConcept C67018056 @default.
- W2613988040 hasConcept C71924100 @default.
- W2613988040 hasConcept C86803240 @default.
- W2613988040 hasConcept C95444343 @default.
- W2613988040 hasConcept C98274493 @default.
- W2613988040 hasConceptScore W2613988040C126322002 @default.
- W2613988040 hasConceptScore W2613988040C150903083 @default.
- W2613988040 hasConceptScore W2613988040C169760540 @default.
- W2613988040 hasConceptScore W2613988040C170493617 @default.