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- W2613999006 abstract "Abstract BACKGROUND Resistance to insecticides through one or several mechanisms has a cost for an insect in various parameters of its biological cycle. The present study evaluated the effect of deltamethrin on detoxifying enzymes and biological parameters in a population of Aedes aegypti selected for 15 generations. The enzyme activities of alpha‐ and beta‐esterases, mixed‐function oxidases and glutathione‐S‐transferases were determined during selection, along with biological parameters. RESULTS Overexpression of mixed‐function oxidases as a mechanism of metabolic resistance to deltamethrin was found. There were decreases in percentages of eggs hatching, pupation and age‐specific survival and in total survival at the end of the selection (F 16 ). Although age‐specific fecundity was not affected by selection with deltamethrin, total fertility, together with lower survival, significantly affected gross reproduction rate, gradually decreasing due to deltamethrin selection. Similarly, net reproductive rate and intrinsic growth rate were affected by selection. CONCLUSION Alterations in life parameters could be due to the accumulation of noxious effects or deleterious genes related to detoxifying enzymes, specifically those coding for mixed‐function oxidases, along with the presence of recessive alleles of the V1016I and F1534C mutations, associating deltamethrin resistance with fitness cost in Ae. aegypti . © 2017 Society of Chemical Industry" @default.
- W2613999006 created "2017-05-19" @default.
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- W2613999006 date "2017-07-24" @default.
- W2613999006 modified "2023-10-17" @default.
- W2613999006 title "Assessing the effect of selection with deltamethrin on biological parameters and detoxifying enzymes in<i>Aedes aegypti</i>(L.)" @default.
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- W2613999006 doi "https://doi.org/10.1002/ps.4609" @default.
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