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- W2614039621 abstract "1468 Hepatocellular carcinoma (HCC) exhibits a unique feature of high frequency of allelic loss at chromosome 4q. Using mRNA differential display, we identified frequent overexpression of alpha-fetoprotein (AFP) at 4q11-q13 and osteopontin (OPN) at 4q21-q25, and downregulation of annexin A10 (ANXA10) at 4q33. This study is to elucidate the clinicopathological significance of the accumulation of the aberrant expressions of these three genes in the progression of HCC using reverse transcriptase polymerase chain reaction (RT-PCR) analyses and radioimmunoassay for AFP. We showed that high AFP levels (>200 ng/ml), OPN overexpression and ANXA10 downregulation had close association with more frequent large HCC (P=0.0002, P=0.0013, and P=0.007, respectively), grade II to IV (P=0.0000, P=0.0001, and P=0.0000, respectively), and portal vein invasion (stage IIIB and IV) (P=0.0000, P=0.0000, and P=0.0001, respectively). Besides, high AFP levels correlated with OPN overexpression (P=0.0001) and ANXA10 downregulation (P=0.0000), while OPN overexpression also correlated with ANXA10 downregulation (P=0.0011). We then analyzed their potential synergistic effects in the tumor progression. We showed that HCCs with all the three genetic aberrations had more frequent large tumors, portal vein invasion, and early tumor recurrence than the other groups (P" @default.
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- W2614039621 date "2004-04-01" @default.
- W2614039621 modified "2023-09-24" @default.
- W2614039621 title "Synergistic effects of aberrant expression of alpha-fetoprotein, annexin A10 and osteopontin at chromosome 4q in the tumor progression, early recurrence and poor prognosis of hepatocellular carcinoma" @default.
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