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- W2614133477 abstract "Mass spectrometry is a sensitive technique used to detect, identify, and quantify molecules based on their m/z . High-performance liquid chromatography (HPLC)4 is a common separation technique used before analysis of biological samples by LC-MS/MS. LC-MS/MS is preferred over immunoassay for therapeutic drug monitoring of immunosuppressive drugs due to its specificity and sensitivity in detecting analytes in liquid and nonvolatile samples. However, time-consuming sample preparation and interferences resulting from ion suppression are among the disadvantages of LC-MS/MS because they can compromise or invalidate results. Also, although the instruments used are more robust, computer-interfaced, user-friendly, and easier to maintain compared with decades ago (1), their technical complexity leads to difficulties in troubleshooting and can be intimidating to laboratorians. Creating exhaustive system checklists …" @default.
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- W2614133477 date "2017-04-18" @default.
- W2614133477 modified "2023-09-23" @default.
- W2614133477 title "You Should Have the Same Area Counts" @default.
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- W2614133477 doi "https://doi.org/10.1373/jalm.2016.022079" @default.
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