Matches in SemOpenAlex for { <https://semopenalex.org/work/W2614173989> ?p ?o ?g. }
- W2614173989 endingPage "40" @default.
- W2614173989 startingPage "28" @default.
- W2614173989 abstract "Pancreatic cancer (PC) is one of the most fatal cancers worldwide. The incidence and death rates are still increasing for PC. Curcumin is the biologically active diarylheptanoid constituent of the spice turmeric, which exerts its anticancer properties in various human cancers including PC. In particular, accumulating evidence has proved that curcumin targets numerous therapeutically important proteins in cell signaling pathways. The neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4) is an E3 HECT ubiquitin ligase and is frequently over-expressed in various cancers. It has reported that NEDD4 might facilitate tumorigenesis via targeting and degradation of multiple tumor suppressor proteins including PTEN. Hence, in the present study we explore whether curcumin inhibits NEDD4, resulting in the suppression of cell growth, migration and invasion in PC cells. We found that curcumin inhibited cell proliferation and triggered apoptosis in PC, which is associated with increased expression of PTEN and p73. These results suggested that inhibition of NEDD4 might be beneficial to the antitumor properties of curcumin on PC treatments." @default.
- W2614173989 created "2017-05-26" @default.
- W2614173989 creator A5011209310 @default.
- W2614173989 creator A5016150318 @default.
- W2614173989 creator A5021707712 @default.
- W2614173989 creator A5032545417 @default.
- W2614173989 creator A5037283153 @default.
- W2614173989 creator A5042015646 @default.
- W2614173989 creator A5069771666 @default.
- W2614173989 creator A5081739217 @default.
- W2614173989 creator A5082599988 @default.
- W2614173989 date "2017-09-01" @default.
- W2614173989 modified "2023-10-15" @default.
- W2614173989 title "The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer" @default.
- W2614173989 cites W1857938233 @default.
- W2614173989 cites W1882059350 @default.
- W2614173989 cites W1945248387 @default.
- W2614173989 cites W1968464875 @default.
- W2614173989 cites W1979339081 @default.
- W2614173989 cites W1979376000 @default.
- W2614173989 cites W1981048326 @default.
- W2614173989 cites W1985671514 @default.
- W2614173989 cites W2003721954 @default.
- W2614173989 cites W2010102311 @default.
- W2614173989 cites W2015709967 @default.
- W2614173989 cites W2015926136 @default.
- W2614173989 cites W2017739035 @default.
- W2614173989 cites W2029439166 @default.
- W2614173989 cites W2041764058 @default.
- W2614173989 cites W2065612142 @default.
- W2614173989 cites W2071962567 @default.
- W2614173989 cites W2078950380 @default.
- W2614173989 cites W2093806359 @default.
- W2614173989 cites W2099658407 @default.
- W2614173989 cites W2118606898 @default.
- W2614173989 cites W2138064708 @default.
- W2614173989 cites W2147047346 @default.
- W2614173989 cites W2158705489 @default.
- W2614173989 cites W2159283304 @default.
- W2614173989 cites W2163268741 @default.
- W2614173989 cites W2235523093 @default.
- W2614173989 cites W2318716029 @default.
- W2614173989 cites W2344638692 @default.
- W2614173989 cites W2482793089 @default.
- W2614173989 cites W2502470328 @default.
- W2614173989 cites W2590341808 @default.
- W2614173989 doi "https://doi.org/10.1016/j.bcp.2017.05.014" @default.
- W2614173989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28535906" @default.
- W2614173989 hasPublicationYear "2017" @default.
- W2614173989 type Work @default.
- W2614173989 sameAs 2614173989 @default.
- W2614173989 citedByCount "40" @default.
- W2614173989 countsByYear W26141739892018 @default.
- W2614173989 countsByYear W26141739892019 @default.
- W2614173989 countsByYear W26141739892020 @default.
- W2614173989 countsByYear W26141739892021 @default.
- W2614173989 countsByYear W26141739892022 @default.
- W2614173989 countsByYear W26141739892023 @default.
- W2614173989 crossrefType "journal-article" @default.
- W2614173989 hasAuthorship W2614173989A5011209310 @default.
- W2614173989 hasAuthorship W2614173989A5016150318 @default.
- W2614173989 hasAuthorship W2614173989A5021707712 @default.
- W2614173989 hasAuthorship W2614173989A5032545417 @default.
- W2614173989 hasAuthorship W2614173989A5037283153 @default.
- W2614173989 hasAuthorship W2614173989A5042015646 @default.
- W2614173989 hasAuthorship W2614173989A5069771666 @default.
- W2614173989 hasAuthorship W2614173989A5081739217 @default.
- W2614173989 hasAuthorship W2614173989A5082599988 @default.
- W2614173989 hasConcept C104317684 @default.
- W2614173989 hasConcept C121608353 @default.
- W2614173989 hasConcept C134459356 @default.
- W2614173989 hasConcept C1491633281 @default.
- W2614173989 hasConcept C185592680 @default.
- W2614173989 hasConcept C190283241 @default.
- W2614173989 hasConcept C25602115 @default.
- W2614173989 hasConcept C2777265272 @default.
- W2614173989 hasConcept C2777609662 @default.
- W2614173989 hasConcept C2778250585 @default.
- W2614173989 hasConcept C2780210213 @default.
- W2614173989 hasConcept C31573885 @default.
- W2614173989 hasConcept C502942594 @default.
- W2614173989 hasConcept C54355233 @default.
- W2614173989 hasConcept C55493867 @default.
- W2614173989 hasConcept C555283112 @default.
- W2614173989 hasConcept C62112901 @default.
- W2614173989 hasConcept C86554907 @default.
- W2614173989 hasConcept C86803240 @default.
- W2614173989 hasConcept C95444343 @default.
- W2614173989 hasConceptScore W2614173989C104317684 @default.
- W2614173989 hasConceptScore W2614173989C121608353 @default.
- W2614173989 hasConceptScore W2614173989C134459356 @default.
- W2614173989 hasConceptScore W2614173989C1491633281 @default.
- W2614173989 hasConceptScore W2614173989C185592680 @default.
- W2614173989 hasConceptScore W2614173989C190283241 @default.
- W2614173989 hasConceptScore W2614173989C25602115 @default.
- W2614173989 hasConceptScore W2614173989C2777265272 @default.
- W2614173989 hasConceptScore W2614173989C2777609662 @default.
- W2614173989 hasConceptScore W2614173989C2778250585 @default.