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• W2614233794 abstract "Abstract Cholera is a life-threatening disease in many countries, and new drugs are clearly needed. C -glycosidic antagonists may serve such a purpose. Here we report atomic-resolution crystal structures of three such compounds in complexes with the cholera toxin. The structures give unprecedented atomic details of the molecular interactions and show how the inhibitors efficiently block the GM1 binding site. These molecules are well suited for development into low-cost prophylactic drugs, due to their relatively easy synthesis and their resistance to glycolytic enzymes. One of the compounds links two toxin B-pentamers in the crystal structure, which may yield improved inhibition through the formation of toxin aggregates. These structures can spark the improved design of GM1 mimics, either alone or as multivalent inhibitors connecting multiple GM1-binding sites. Future developments may further include compounds that link the primary and secondary binding sites. Serving as decoys, receptor mimics may lessen symptoms while avoiding the use of antibiotics." @default.
• W2614233794 created "2017-05-26" @default.
• W2614233794 creator A5007345344 @default.
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• W2614233794 date "2017-05-24" @default.
• W2614233794 modified "2023-10-12" @default.
• W2614233794 title "Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics" @default.
• W2614233794 cites W1146611889 @default.
• W2614233794 cites W1545717845 @default.
• W2614233794 cites W1573127893 @default.
• W2614233794 cites W1743689021 @default.
• W2614233794 cites W1843522855 @default.
• W2614233794 cites W1885689715 @default.
• W2614233794 cites W1969547178 @default.
• W2614233794 cites W1974838772 @default.
• W2614233794 cites W1978319672 @default.
• W2614233794 cites W1979700521 @default.
• W2614233794 cites W1981154770 @default.
• W2614233794 cites W1987961110 @default.
• W2614233794 cites W1992888087 @default.
• W2614233794 cites W1996855722 @default.
• W2614233794 cites W1998840756 @default.
• W2614233794 cites W2004032200 @default.
• W2614233794 cites W2004835943 @default.
• W2614233794 cites W2009084519 @default.
• W2614233794 cites W2009155017 @default.
• W2614233794 cites W2010165887 @default.
• W2614233794 cites W2018585738 @default.
• W2614233794 cites W2019274549 @default.
• W2614233794 cites W2024755413 @default.
• W2614233794 cites W2030490593 @default.
• W2614233794 cites W2032377822 @default.
• W2614233794 cites W2033414086 @default.
• W2614233794 cites W2036477493 @default.
• W2614233794 cites W2036807411 @default.
• W2614233794 cites W2038284222 @default.
• W2614233794 cites W2043402450 @default.
• W2614233794 cites W2046782619 @default.
• W2614233794 cites W2052022792 @default.
• W2614233794 cites W2053094735 @default.
• W2614233794 cites W2053705601 @default.
• W2614233794 cites W2054159506 @default.
• W2614233794 cites W2062591183 @default.
• W2614233794 cites W2077765391 @default.
• W2614233794 cites W2083237454 @default.
• W2614233794 cites W2104510609 @default.
• W2614233794 cites W2105019124 @default.
• W2614233794 cites W2108921801 @default.
• W2614233794 cites W2108959691 @default.
• W2614233794 cites W2109971510 @default.
• W2614233794 cites W2112667325 @default.
• W2614233794 cites W2113086326 @default.
• W2614233794 cites W2114367386 @default.
• W2614233794 cites W2114547141 @default.
• W2614233794 cites W2121199753 @default.
• W2614233794 cites W2124026197 @default.
• W2614233794 cites W2124864045 @default.
• W2614233794 cites W2125428954 @default.
• W2614233794 cites W2126314393 @default.
• W2614233794 cites W2129493493 @default.
• W2614233794 cites W2139813645 @default.
• W2614233794 cites W2141435696 @default.
• W2614233794 cites W2141986488 @default.
• W2614233794 cites W2142680783 @default.
• W2614233794 cites W2143594298 @default.
• W2614233794 cites W2145439094 @default.
• W2614233794 cites W2146080841 @default.
• W2614233794 cites W2147949826 @default.
• W2614233794 cites W2150651714 @default.
• W2614233794 cites W2151752127 @default.
• W2614233794 cites W2159211495 @default.
• W2614233794 cites W2166133779 @default.
• W2614233794 cites W2167006138 @default.
• W2614233794 cites W2239961489 @default.
• W2614233794 cites W2305834606 @default.
• W2614233794 cites W2309663145 @default.
• W2614233794 cites W2342337884 @default.
• W2614233794 cites W2399720124 @default.
• W2614233794 cites W2472202054 @default.
• W2614233794 cites W2550051678 @default.
• W2614233794 cites W2587232953 @default.
• W2614233794 cites W2950805044 @default.
• W2614233794 cites W4211176329 @default.
• W2614233794 cites W4211207408 @default.
• W2614233794 cites W4243919487 @default.
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• W2614233794 doi "https://doi.org/10.1038/s41598-017-02179-0" @default.
• W2614233794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5443773" @default.
• W2614233794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28539625" @default.
• W2614233794 hasPublicationYear "2017" @default.
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