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• W2614291230 abstract "The Src-family tyrosine kinase Lck is an enzyme associated with the CD4 and CD8 co-receptors and promoting signaling through the T cell receptor (TCR) complex. The levels of Lck expression and activity change during the development and differentiation of T cells. Here we show that Lck expression is higher in Th1 cells as compared to Th2 cells. Ectopic overexpression of Lck in Th2 cells results in increased expression of CD4 co-receptor and enhanced S73 phosphorylation of transcription factor c-Jun. Our findings indicate that TCR-mediated signaling in Th2 cells may be directly attenuated by Lck protein expression level." @default.
• W2614291230 created "2017-05-26" @default.
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• W2614291230 date "2017-05-24" @default.
• W2614291230 modified "2023-09-26" @default.
• W2614291230 title "Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun" @default.
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• W2614291230 doi "https://doi.org/10.1038/s41598-017-02553-y" @default.
• W2614291230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5443812" @default.
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• W2614291230 hasPublicationYear "2017" @default.
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