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- W2614344531 endingPage "674" @default.
- W2614344531 startingPage "659" @default.
- W2614344531 abstract "Introduction: With the discovery of imatinib mesylate nearly 20 years ago, tyrosine kinase inhibitors (TKIs) were found to be effective in chronic myeloid leukemia (CML). TKI therapy has since revolutionized the treatment of CML and has served as a paradigm of success for targeted drug therapy in cancer. Several new TKIs for CML have been approved over the last two decades that exhibit improved potency over imatinib and have different off-target profiles, providing options for individualized therapy selection.Areas covered: Current management of chronic phase CML, including guidance on the sequential use of imatinib and newer-generation TKIs and evolving treatment strategies such as TKI discontinuation. Relevant literature was identified by searching biomedical databases (i.e. PubMed) for primary research material.Expert commentary: Although survival outcomes have drastically improved for CML patients, treatment for CML has grown more complex with the introduction of next-generation TKIs and the advent of treatment-free remissions (TFR). Goals of therapy have shifted accordingly, with increased focus on improving quality of life, managing patient expectations and optimizing patient adherence." @default.
- W2614344531 created "2017-05-26" @default.
- W2614344531 creator A5041829729 @default.
- W2614344531 creator A5066701178 @default.
- W2614344531 creator A5082566267 @default.
- W2614344531 date "2017-05-22" @default.
- W2614344531 modified "2023-10-02" @default.
- W2614344531 title "Treating the chronic-phase chronic myeloid leukemia patient: which TKI, when to switch and when to stop?" @default.
- W2614344531 cites W1490900965 @default.
- W2614344531 cites W1565948695 @default.
- W2614344531 cites W1698264213 @default.
- W2614344531 cites W178680177 @default.
- W2614344531 cites W1827459324 @default.
- W2614344531 cites W18488647 @default.
- W2614344531 cites W1919069136 @default.
- W2614344531 cites W1939978733 @default.
- W2614344531 cites W1944560152 @default.
- W2614344531 cites W1964138924 @default.
- W2614344531 cites W1966239454 @default.
- W2614344531 cites W1968232397 @default.
- W2614344531 cites W1968747503 @default.
- W2614344531 cites W1969672788 @default.
- W2614344531 cites W1971940453 @default.
- W2614344531 cites W1974357959 @default.
- W2614344531 cites W1975541563 @default.
- W2614344531 cites W1977996924 @default.
- W2614344531 cites W1980643173 @default.
- W2614344531 cites W1981256536 @default.
- W2614344531 cites W1987316203 @default.
- W2614344531 cites W1992121712 @default.
- W2614344531 cites W1992579939 @default.
- W2614344531 cites W1995670055 @default.
- W2614344531 cites W1998406030 @default.
- W2614344531 cites W2001335864 @default.
- W2614344531 cites W2009214080 @default.
- W2614344531 cites W2010678043 @default.
- W2614344531 cites W2014316424 @default.
- W2614344531 cites W2014839361 @default.
- W2614344531 cites W2016960626 @default.
- W2614344531 cites W2019633460 @default.
- W2614344531 cites W2021095507 @default.
- W2614344531 cites W2021188441 @default.
- W2614344531 cites W2021648831 @default.
- W2614344531 cites W2025854230 @default.
- W2614344531 cites W2027744772 @default.
- W2614344531 cites W2028160317 @default.
- W2614344531 cites W2028959752 @default.
- W2614344531 cites W2030752829 @default.
- W2614344531 cites W2033661259 @default.
- W2614344531 cites W2035278640 @default.
- W2614344531 cites W2039949576 @default.
- W2614344531 cites W2041271955 @default.
- W2614344531 cites W2045088371 @default.
- W2614344531 cites W2050904392 @default.
- W2614344531 cites W2052054991 @default.
- W2614344531 cites W2052923507 @default.
- W2614344531 cites W2057796192 @default.
- W2614344531 cites W2057827171 @default.
- W2614344531 cites W2058216377 @default.
- W2614344531 cites W2059705970 @default.
- W2614344531 cites W2064367288 @default.
- W2614344531 cites W2067529738 @default.
- W2614344531 cites W2072703295 @default.
- W2614344531 cites W2076720738 @default.
- W2614344531 cites W2076869962 @default.
- W2614344531 cites W2081813128 @default.
- W2614344531 cites W2085342571 @default.
- W2614344531 cites W2091423586 @default.
- W2614344531 cites W2097799776 @default.
- W2614344531 cites W2099747692 @default.
- W2614344531 cites W2102097468 @default.
- W2614344531 cites W2102999107 @default.
- W2614344531 cites W2105783133 @default.
- W2614344531 cites W2106392592 @default.
- W2614344531 cites W2109619078 @default.
- W2614344531 cites W2111072132 @default.
- W2614344531 cites W2112810605 @default.
- W2614344531 cites W2115626434 @default.
- W2614344531 cites W2117356576 @default.
- W2614344531 cites W2117806883 @default.
- W2614344531 cites W2119010176 @default.
- W2614344531 cites W2124068666 @default.
- W2614344531 cites W2126579741 @default.
- W2614344531 cites W2128738046 @default.
- W2614344531 cites W2136703362 @default.
- W2614344531 cites W2138494642 @default.
- W2614344531 cites W2140351909 @default.
- W2614344531 cites W2140974115 @default.
- W2614344531 cites W2143939343 @default.
- W2614344531 cites W2147109509 @default.
- W2614344531 cites W2148743957 @default.
- W2614344531 cites W2155615242 @default.
- W2614344531 cites W2156145496 @default.
- W2614344531 cites W2160851769 @default.
- W2614344531 cites W2170475006 @default.
- W2614344531 cites W2172189430 @default.
- W2614344531 cites W2179788614 @default.
- W2614344531 cites W2189113171 @default.