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• W2614423009 abstract "Background Oral anticoagulation ( OAC ) therapy is associated with increased periprocedural risks after cardiac implantable electronic device ( CIED ) implantation. Patterns of anticoagulation management involving non–vitamin K antagonist oral anticoagulants ( NOACs ) have not been characterized. Hypothesis Anticoagulation strategies and outcomes differ by anticoagulant type in patients undergoing CIED implantation. Methods Using the nationwide Outcomes Registry for Better Informed Treatment of Atrial Fibrillation, we assessed how atrial fibrillation ( AF ) patients undergoing CIED implantation were cared for and their subsequent outcomes. Outcomes were compared by oral anticoagulant therapy (none, warfarin, or NOAC ) as well as by anticoagulation interruption status. Results Among 9129 AF patients, 416 (5%) underwent CIED implantation during a median follow‐up of 30 months (interquartile range, 24–36). Of these, 60 (14%) had implantation on a NOAC . Relative to warfarin therapy, those on a NOAC were younger (70.5 years [range, 65–77.5 years] vs 77 years [range, 70–82 years]), had less valvular heart disease (15.0% vs 31.3%), higher creatinine clearance (67.3 [range, 59.7–99.0] vs 65.8 [range, 50.0–91.6]), were more likely to have persistent AF (26.7% vs 22.9%), and use concomitant aspirin (51.7% vs 35.2%). OAC therapy was commonly interrupted for CIED in 64% (n = 183 of 284) of warfarin patients and 65% (n = 39 of 60) of NOAC patients. Many interrupted patients received intravenous bridging anticoagulation: 33/183 (18%) interrupted warfarin and 4/39 (10%) interrupted NOAC patients. Thirty‐day periprocedure bleeding and stroke adverse events were infrequent. Conclusions Management of anticoagulation among AF patients undergoing CIED implantation is highly variable, with OAC being interrupted in more than half of both warfarin‐ and NOAC ‐treated patients. Bleeding and stroke events were infrequent in both warfarin and NOAC ‐treated patients." @default.
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• W2614423009 date "2017-05-19" @default.
• W2614423009 modified "2023-10-01" @default.
• W2614423009 title "Oral anticoagulation management in patients with atrial fibrillation undergoing cardiac implantable electronic device implantation" @default.
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• W2614423009 doi "https://doi.org/10.1002/clc.22726" @default.
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