Matches in SemOpenAlex for { <https://semopenalex.org/work/W2614501214> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2614501214 abstract "Genetic association studies lead to simultaneous categorical data analysis. The sample for every genetic locus consists of a contingency table containing the numbers of observed genotype-phenotype combinations. Under case-control design, the row counts of every table are identical and fixed, while column counts are random. The aim of the statistical analysis is to test independence of the phenotype and the genotype at every locus. We present an objective Bayesian methodology for these association tests, which relies on the conjugacy of Dirichlet and multinomial distributions. Being based on the likelihood principle, the Bayesian tests avoid looping over all tables with given marginals. Making use of data generated by The Wellcome Trust Case Control Consortium (WTCCC), we illustrate that the ordering of the Bayes factors shows a good agreement with that of frequentist p-values. Furthermore, we deal with specifying prior probabilities for the validity of the null hypotheses, by taking linkage disequilibrium structure into account and exploiting the concept of effective numbers of tests. Application of a Bayesian decision theoretic multiple test procedure to the WTCCC data illustrates the proposed methodology. Finally, we discuss two methods for reconciling frequentist and Bayesian approaches to the multiple association test problem." @default.
- W2614501214 created "2017-05-26" @default.
- W2614501214 creator A5026392908 @default.
- W2614501214 date "2014-08-29" @default.
- W2614501214 modified "2023-09-26" @default.
- W2614501214 title "Simultaneous Bayesian analysis of contingency tables in genetic association studies" @default.
- W2614501214 hasPublicationYear "2014" @default.
- W2614501214 type Work @default.
- W2614501214 sameAs 2614501214 @default.
- W2614501214 citedByCount "0" @default.
- W2614501214 crossrefType "journal-article" @default.
- W2614501214 hasAuthorship W2614501214A5026392908 @default.
- W2614501214 hasConcept C105795698 @default.
- W2614501214 hasConcept C107673813 @default.
- W2614501214 hasConcept C142291917 @default.
- W2614501214 hasConcept C149782125 @default.
- W2614501214 hasConcept C160234255 @default.
- W2614501214 hasConcept C162376815 @default.
- W2614501214 hasConcept C207201462 @default.
- W2614501214 hasConcept C33923547 @default.
- W2614501214 hasConcept C5274069 @default.
- W2614501214 hasConcept C91998498 @default.
- W2614501214 hasConceptScore W2614501214C105795698 @default.
- W2614501214 hasConceptScore W2614501214C107673813 @default.
- W2614501214 hasConceptScore W2614501214C142291917 @default.
- W2614501214 hasConceptScore W2614501214C149782125 @default.
- W2614501214 hasConceptScore W2614501214C160234255 @default.
- W2614501214 hasConceptScore W2614501214C162376815 @default.
- W2614501214 hasConceptScore W2614501214C207201462 @default.
- W2614501214 hasConceptScore W2614501214C33923547 @default.
- W2614501214 hasConceptScore W2614501214C5274069 @default.
- W2614501214 hasConceptScore W2614501214C91998498 @default.
- W2614501214 hasLocation W26145012141 @default.
- W2614501214 hasOpenAccess W2614501214 @default.
- W2614501214 hasPrimaryLocation W26145012141 @default.
- W2614501214 hasRelatedWork W1493676321 @default.
- W2614501214 hasRelatedWork W1535384920 @default.
- W2614501214 hasRelatedWork W1540255359 @default.
- W2614501214 hasRelatedWork W1755128971 @default.
- W2614501214 hasRelatedWork W1943429024 @default.
- W2614501214 hasRelatedWork W1966271080 @default.
- W2614501214 hasRelatedWork W1976163512 @default.
- W2614501214 hasRelatedWork W1989443960 @default.
- W2614501214 hasRelatedWork W2041511033 @default.
- W2614501214 hasRelatedWork W2068252077 @default.
- W2614501214 hasRelatedWork W2130670110 @default.
- W2614501214 hasRelatedWork W2135173838 @default.
- W2614501214 hasRelatedWork W2147962921 @default.
- W2614501214 hasRelatedWork W2160653042 @default.
- W2614501214 hasRelatedWork W2188439980 @default.
- W2614501214 hasRelatedWork W2272384150 @default.
- W2614501214 hasRelatedWork W2585701800 @default.
- W2614501214 hasRelatedWork W2769918272 @default.
- W2614501214 hasRelatedWork W2896875340 @default.
- W2614501214 hasRelatedWork W70906395 @default.
- W2614501214 isParatext "false" @default.
- W2614501214 isRetracted "false" @default.
- W2614501214 magId "2614501214" @default.
- W2614501214 workType "article" @default.