Matches in SemOpenAlex for { <https://semopenalex.org/work/W2614541251> ?p ?o ?g. }
- W2614541251 endingPage "e0177834" @default.
- W2614541251 startingPage "e0177834" @default.
- W2614541251 abstract "Circadian rhythms are intrinsic ~24 hour cycles that regulate diverse aspects of physiology, and in turn are regulated by interactions with the external environment. Casein kinase 1 delta (CK1δ, CSNK1D) is a key regulator of the clock, phosphorylating both stabilizing and destabilizing sites on the PER2 protein, in a mechanism known as the phosphoswitch. CK1δ can itself be regulated by phosphorylation on its regulatory domain, but the specific sites involved, and the role this plays in control of circadian rhythms as well as other CK1-dependent processes is not well understood. Using a sensitized PER2::LUC reporter assay, we identified a specific phosphorylation site, T347, on CK1δ, that regulates CK1δ activity towards PER2. A mutant CK1δ T347A was more active in promoting PER2 degradation. This CK1δ regulatory site is phosphorylated in cells in trans by dinaciclib- and staurosporine-sensitive kinases, consistent with their potential regulation by cyclin dependent and other proline-directed kinases. The regulation of CK1δ by site-specific phosphorylation via the cell cycle and other signaling pathways provides a mechanism to couple external stimuli to regulation of CK1δ-dependent pathways including the circadian clock." @default.
- W2614541251 created "2017-05-26" @default.
- W2614541251 creator A5026530871 @default.
- W2614541251 creator A5028126403 @default.
- W2614541251 creator A5043509586 @default.
- W2614541251 date "2017-05-17" @default.
- W2614541251 modified "2023-10-17" @default.
- W2614541251 title "Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2" @default.
- W2614541251 cites W1832030339 @default.
- W2614541251 cites W1909535318 @default.
- W2614541251 cites W1964207717 @default.
- W2614541251 cites W1972144091 @default.
- W2614541251 cites W1972331693 @default.
- W2614541251 cites W1974495707 @default.
- W2614541251 cites W1984363659 @default.
- W2614541251 cites W1986603094 @default.
- W2614541251 cites W1989011389 @default.
- W2614541251 cites W1990192893 @default.
- W2614541251 cites W1990361088 @default.
- W2614541251 cites W1997179110 @default.
- W2614541251 cites W2011636905 @default.
- W2614541251 cites W2012753167 @default.
- W2614541251 cites W2014313900 @default.
- W2614541251 cites W2014422314 @default.
- W2614541251 cites W2019727473 @default.
- W2614541251 cites W2028940017 @default.
- W2614541251 cites W2041216483 @default.
- W2614541251 cites W2042642676 @default.
- W2614541251 cites W2043274355 @default.
- W2614541251 cites W2043746099 @default.
- W2614541251 cites W2053802535 @default.
- W2614541251 cites W2058981124 @default.
- W2614541251 cites W2060977391 @default.
- W2614541251 cites W2062239697 @default.
- W2614541251 cites W2066546742 @default.
- W2614541251 cites W2067633308 @default.
- W2614541251 cites W2085037886 @default.
- W2614541251 cites W2086747574 @default.
- W2614541251 cites W2093478869 @default.
- W2614541251 cites W2101400842 @default.
- W2614541251 cites W2114428498 @default.
- W2614541251 cites W2117583882 @default.
- W2614541251 cites W2124659015 @default.
- W2614541251 cites W2124659072 @default.
- W2614541251 cites W2136714385 @default.
- W2614541251 cites W2140642045 @default.
- W2614541251 cites W2160091872 @default.
- W2614541251 cites W2162650381 @default.
- W2614541251 cites W2165688051 @default.
- W2614541251 cites W2169326906 @default.
- W2614541251 cites W2553948355 @default.
- W2614541251 cites W2560772587 @default.
- W2614541251 cites W314393173 @default.
- W2614541251 doi "https://doi.org/10.1371/journal.pone.0177834" @default.
- W2614541251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5435336" @default.
- W2614541251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28545154" @default.
- W2614541251 hasPublicationYear "2017" @default.
- W2614541251 type Work @default.
- W2614541251 sameAs 2614541251 @default.
- W2614541251 citedByCount "40" @default.
- W2614541251 countsByYear W26145412512018 @default.
- W2614541251 countsByYear W26145412512019 @default.
- W2614541251 countsByYear W26145412512020 @default.
- W2614541251 countsByYear W26145412512021 @default.
- W2614541251 countsByYear W26145412512022 @default.
- W2614541251 countsByYear W26145412512023 @default.
- W2614541251 crossrefType "journal-article" @default.
- W2614541251 hasAuthorship W2614541251A5026530871 @default.
- W2614541251 hasAuthorship W2614541251A5028126403 @default.
- W2614541251 hasAuthorship W2614541251A5043509586 @default.
- W2614541251 hasBestOaLocation W26145412511 @default.
- W2614541251 hasConcept C104317684 @default.
- W2614541251 hasConcept C11960822 @default.
- W2614541251 hasConcept C121446783 @default.
- W2614541251 hasConcept C134018914 @default.
- W2614541251 hasConcept C160110348 @default.
- W2614541251 hasConcept C184235292 @default.
- W2614541251 hasConcept C184738001 @default.
- W2614541251 hasConcept C2779064383 @default.
- W2614541251 hasConcept C38606739 @default.
- W2614541251 hasConcept C55493867 @default.
- W2614541251 hasConcept C6929976 @default.
- W2614541251 hasConcept C86803240 @default.
- W2614541251 hasConcept C95444343 @default.
- W2614541251 hasConcept C97029542 @default.
- W2614541251 hasConceptScore W2614541251C104317684 @default.
- W2614541251 hasConceptScore W2614541251C11960822 @default.
- W2614541251 hasConceptScore W2614541251C121446783 @default.
- W2614541251 hasConceptScore W2614541251C134018914 @default.
- W2614541251 hasConceptScore W2614541251C160110348 @default.
- W2614541251 hasConceptScore W2614541251C184235292 @default.
- W2614541251 hasConceptScore W2614541251C184738001 @default.
- W2614541251 hasConceptScore W2614541251C2779064383 @default.
- W2614541251 hasConceptScore W2614541251C38606739 @default.
- W2614541251 hasConceptScore W2614541251C55493867 @default.
- W2614541251 hasConceptScore W2614541251C6929976 @default.
- W2614541251 hasConceptScore W2614541251C86803240 @default.
- W2614541251 hasConceptScore W2614541251C95444343 @default.