Matches in SemOpenAlex for { <https://semopenalex.org/work/W2614668369> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2614668369 abstract "Abstract Dibenzo- and benzindolo-azecines represent a class of potential neuroleptics. To characterize the effectiveness at the dopamine and 5-HT2A-receptor representative structures were synthesized and tested by radio ligand binding studies, in vivo and in vitro studies. Neuroleptic potency and the risk of side effects of the prodrug 7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-yl isobutyrate, an ester derivative of the most promising azecine 7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-ol (LE404), was tested in vivo concerning conditioned avoidance response inhibition, locomotor activity and triggering of catalepsy vs. haloperidol as a reference. Also ester hydrolysis was examined using porcine liver esterase to thereby obtain an indication of the stability of the prodrug in vivo. An HPLC method was developed for purity control and determination of octanol/water-distribution coefficients. It has been shown that the tested substances in their efficacy are comparable to haloperidol and risperidone, but the therapeutic index in most cases is larger. Esterification as a prodrug principle leads to significantly prolonged effectiveness." @default.
- W2614668369 created "2017-05-26" @default.
- W2614668369 creator A5036286838 @default.
- W2614668369 creator A5037674039 @default.
- W2614668369 creator A5051936357 @default.
- W2614668369 creator A5053222555 @default.
- W2614668369 creator A5056221994 @default.
- W2614668369 date "2017-05-18" @default.
- W2614668369 modified "2023-09-25" @default.
- W2614668369 title "Synthesis and Characterization of new Azecine-Derivatives as Potential Neuroleptics" @default.
- W2614668369 cites W1486547351 @default.
- W2614668369 cites W1966301452 @default.
- W2614668369 cites W1999898236 @default.
- W2614668369 cites W2002916702 @default.
- W2614668369 cites W2004740168 @default.
- W2614668369 cites W2012798378 @default.
- W2614668369 cites W2025498375 @default.
- W2614668369 cites W2029915913 @default.
- W2614668369 cites W2054763364 @default.
- W2614668369 cites W2077253486 @default.
- W2614668369 cites W2079494680 @default.
- W2614668369 cites W2090361336 @default.
- W2614668369 cites W2099576957 @default.
- W2614668369 cites W2109481947 @default.
- W2614668369 cites W2109865728 @default.
- W2614668369 cites W2110148834 @default.
- W2614668369 cites W2122995608 @default.
- W2614668369 cites W2162442934 @default.
- W2614668369 cites W2314131667 @default.
- W2614668369 cites W2321929586 @default.
- W2614668369 cites W2329966862 @default.
- W2614668369 cites W2398499702 @default.
- W2614668369 cites W2951199311 @default.
- W2614668369 doi "https://doi.org/10.1055/s-0043-108651" @default.
- W2614668369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28521372" @default.
- W2614668369 hasPublicationYear "2017" @default.
- W2614668369 type Work @default.
- W2614668369 sameAs 2614668369 @default.
- W2614668369 citedByCount "3" @default.
- W2614668369 countsByYear W26146683692017 @default.
- W2614668369 countsByYear W26146683692018 @default.
- W2614668369 countsByYear W26146683692021 @default.
- W2614668369 crossrefType "journal-article" @default.
- W2614668369 hasAuthorship W2614668369A5036286838 @default.
- W2614668369 hasAuthorship W2614668369A5037674039 @default.
- W2614668369 hasAuthorship W2614668369A5051936357 @default.
- W2614668369 hasAuthorship W2614668369A5053222555 @default.
- W2614668369 hasAuthorship W2614668369A5056221994 @default.
- W2614668369 hasConcept C108215921 @default.
- W2614668369 hasConcept C126322002 @default.
- W2614668369 hasConcept C150903083 @default.
- W2614668369 hasConcept C185592680 @default.
- W2614668369 hasConcept C202751555 @default.
- W2614668369 hasConcept C207001950 @default.
- W2614668369 hasConcept C2780476085 @default.
- W2614668369 hasConcept C2780948584 @default.
- W2614668369 hasConcept C2781353949 @default.
- W2614668369 hasConcept C513476851 @default.
- W2614668369 hasConcept C55493867 @default.
- W2614668369 hasConcept C57992300 @default.
- W2614668369 hasConcept C71240020 @default.
- W2614668369 hasConcept C71924100 @default.
- W2614668369 hasConcept C86803240 @default.
- W2614668369 hasConcept C98274493 @default.
- W2614668369 hasConceptScore W2614668369C108215921 @default.
- W2614668369 hasConceptScore W2614668369C126322002 @default.
- W2614668369 hasConceptScore W2614668369C150903083 @default.
- W2614668369 hasConceptScore W2614668369C185592680 @default.
- W2614668369 hasConceptScore W2614668369C202751555 @default.
- W2614668369 hasConceptScore W2614668369C207001950 @default.
- W2614668369 hasConceptScore W2614668369C2780476085 @default.
- W2614668369 hasConceptScore W2614668369C2780948584 @default.
- W2614668369 hasConceptScore W2614668369C2781353949 @default.
- W2614668369 hasConceptScore W2614668369C513476851 @default.
- W2614668369 hasConceptScore W2614668369C55493867 @default.
- W2614668369 hasConceptScore W2614668369C57992300 @default.
- W2614668369 hasConceptScore W2614668369C71240020 @default.
- W2614668369 hasConceptScore W2614668369C71924100 @default.
- W2614668369 hasConceptScore W2614668369C86803240 @default.
- W2614668369 hasConceptScore W2614668369C98274493 @default.
- W2614668369 hasLocation W26146683691 @default.
- W2614668369 hasLocation W26146683692 @default.
- W2614668369 hasOpenAccess W2614668369 @default.
- W2614668369 hasPrimaryLocation W26146683691 @default.
- W2614668369 hasRelatedWork W1514700806 @default.
- W2614668369 hasRelatedWork W1963900447 @default.
- W2614668369 hasRelatedWork W2078706145 @default.
- W2614668369 hasRelatedWork W2096692295 @default.
- W2614668369 hasRelatedWork W2146091186 @default.
- W2614668369 hasRelatedWork W2194824303 @default.
- W2614668369 hasRelatedWork W2415351295 @default.
- W2614668369 hasRelatedWork W2614668369 @default.
- W2614668369 hasRelatedWork W3013349267 @default.
- W2614668369 hasRelatedWork W2278677140 @default.
- W2614668369 isParatext "false" @default.
- W2614668369 isRetracted "false" @default.
- W2614668369 magId "2614668369" @default.
- W2614668369 workType "article" @default.