Matches in SemOpenAlex for { <https://semopenalex.org/work/W2614680095> ?p ?o ?g. }
- W2614680095 endingPage "4707" @default.
- W2614680095 startingPage "4697" @default.
- W2614680095 abstract "ABSTRACT Reactive oxygen species (ROS) play both deleterious and beneficial roles in cancer cells. Nucleophosmin (NPM) is heavily implicated in cancers of diverse origins, being its gene over‐expression in solid tumors or frequent mutations in hematological malignancies. However, the role and regulatory mechanism of NPM in oxidative stress are unclear. Here, we found that NPM regulated the expression of peroxiredoxin 6 (PRDX6), a member of thiol‐specific antioxidant protein family, consequently affected the level and distribution of ROS. Our data indicated that NPM knockdown caused the increase of ROS and its relocation from cytoplasm to nucleoplasm. In contrast, overexpression or cytoplasmic localization of NPM upregulated PRDX6, and decreased ROS. In addition, NPM knockdown decreased peroxiredoxin family proteins, including PRDX1, PRDX4, and PRDX6. Co‐immunoprecipitation further confirmed the interaction between PRDX6 and NPM. Moreover, NSC348884, an inhibitor specifically targeting NPM oligomerization, decreased PRDX6 and significantly upregulated ROS. These observations demonstrated that the expression and localization of NPM affected the homeostatic balance of oxidative stress in tumor cells via PRDX6 protein. The regulation axis of NPM/PRDX/ROS may provide a novel therapeutic target for cancer treatment. J. Cell. Biochem. 118: 4697–4707, 2017. © 2017 Wiley Periodicals, Inc." @default.
- W2614680095 created "2017-05-26" @default.
- W2614680095 creator A5024203788 @default.
- W2614680095 creator A5025827339 @default.
- W2614680095 creator A5030712224 @default.
- W2614680095 creator A5033073898 @default.
- W2614680095 creator A5033851605 @default.
- W2614680095 creator A5047366974 @default.
- W2614680095 creator A5052725471 @default.
- W2614680095 creator A5087417056 @default.
- W2614680095 creator A5089872052 @default.
- W2614680095 date "2017-06-12" @default.
- W2614680095 modified "2023-10-14" @default.
- W2614680095 title "Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6" @default.
- W2614680095 cites W1523679923 @default.
- W2614680095 cites W1844785966 @default.
- W2614680095 cites W1937750778 @default.
- W2614680095 cites W1967501957 @default.
- W2614680095 cites W1975587831 @default.
- W2614680095 cites W1975967265 @default.
- W2614680095 cites W1977992135 @default.
- W2614680095 cites W1978981036 @default.
- W2614680095 cites W1982217935 @default.
- W2614680095 cites W1992767638 @default.
- W2614680095 cites W1997117872 @default.
- W2614680095 cites W2012181651 @default.
- W2614680095 cites W2013815403 @default.
- W2614680095 cites W2017745794 @default.
- W2614680095 cites W2020950350 @default.
- W2614680095 cites W2032054503 @default.
- W2614680095 cites W2037257739 @default.
- W2614680095 cites W2039260633 @default.
- W2614680095 cites W2048553024 @default.
- W2614680095 cites W2051343147 @default.
- W2614680095 cites W2053268329 @default.
- W2614680095 cites W2055677368 @default.
- W2614680095 cites W2056815934 @default.
- W2614680095 cites W2059647376 @default.
- W2614680095 cites W2061972685 @default.
- W2614680095 cites W2069849780 @default.
- W2614680095 cites W2072383205 @default.
- W2614680095 cites W2073953907 @default.
- W2614680095 cites W2078145793 @default.
- W2614680095 cites W2080363706 @default.
- W2614680095 cites W2085324493 @default.
- W2614680095 cites W2087736884 @default.
- W2614680095 cites W2091405727 @default.
- W2614680095 cites W2094560736 @default.
- W2614680095 cites W2098058376 @default.
- W2614680095 cites W2102043854 @default.
- W2614680095 cites W2111165466 @default.
- W2614680095 cites W2118210890 @default.
- W2614680095 cites W2121997805 @default.
- W2614680095 cites W2134967635 @default.
- W2614680095 cites W2162874229 @default.
- W2614680095 cites W2164725970 @default.
- W2614680095 cites W2185611153 @default.
- W2614680095 cites W2285026225 @default.
- W2614680095 cites W2330101120 @default.
- W2614680095 cites W2346278141 @default.
- W2614680095 cites W2434904135 @default.
- W2614680095 cites W2465673666 @default.
- W2614680095 cites W2467100865 @default.
- W2614680095 cites W2510495333 @default.
- W2614680095 cites W2519786994 @default.
- W2614680095 cites W2527325622 @default.
- W2614680095 cites W2553622516 @default.
- W2614680095 doi "https://doi.org/10.1002/jcb.26135" @default.
- W2614680095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28513872" @default.
- W2614680095 hasPublicationYear "2017" @default.
- W2614680095 type Work @default.
- W2614680095 sameAs 2614680095 @default.
- W2614680095 citedByCount "15" @default.
- W2614680095 countsByYear W26146800952018 @default.
- W2614680095 countsByYear W26146800952019 @default.
- W2614680095 countsByYear W26146800952020 @default.
- W2614680095 countsByYear W26146800952021 @default.
- W2614680095 countsByYear W26146800952022 @default.
- W2614680095 countsByYear W26146800952023 @default.
- W2614680095 crossrefType "journal-article" @default.
- W2614680095 hasAuthorship W2614680095A5024203788 @default.
- W2614680095 hasAuthorship W2614680095A5025827339 @default.
- W2614680095 hasAuthorship W2614680095A5030712224 @default.
- W2614680095 hasAuthorship W2614680095A5033073898 @default.
- W2614680095 hasAuthorship W2614680095A5033851605 @default.
- W2614680095 hasAuthorship W2614680095A5047366974 @default.
- W2614680095 hasAuthorship W2614680095A5052725471 @default.
- W2614680095 hasAuthorship W2614680095A5087417056 @default.
- W2614680095 hasAuthorship W2614680095A5089872052 @default.
- W2614680095 hasConcept C104317684 @default.
- W2614680095 hasConcept C127561419 @default.
- W2614680095 hasConcept C153911025 @default.
- W2614680095 hasConcept C162008176 @default.
- W2614680095 hasConcept C173396325 @default.
- W2614680095 hasConcept C181199279 @default.
- W2614680095 hasConcept C185592680 @default.
- W2614680095 hasConcept C190062978 @default.
- W2614680095 hasConcept C190283241 @default.