Matches in SemOpenAlex for { <https://semopenalex.org/work/W2614818158> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2614818158 endingPage "S23" @default.
- W2614818158 startingPage "S23" @default.
- W2614818158 abstract "Introduction: Cardiac transplantation is the main intervention for patients with end-stage heart failure. Despite great improvements in maintenance immunosuppressive therapies, acute allograft rejection remains a clinical problem. Timely detection of moderate rejection allows for treatment to be modified, preventing organ damage, graft failure and patient death. Regular monitoring for rejection is thus crucial. The endomyocardial biopsy (EMB) is the current standard for monitoring the allograft, but the procedure is highly invasive and costly. Consequently, there is great interest in developing blood-based biomarker tests to monitor for allograft rejection. Blood is a complex tissue, however, and accounting for its dynamic cellular heterogeneity is likely key to identifying robust biomarkers. We investigated whether integrating cellular composition estimates can lead to better performing biomarkers in the context of acute cardiac allograft rejection. Methods: Genome-wide transcript abundance was assayed from PAXgene peripheral whole blood samples obtained from patients undergoing biopsy-confirmed acute allograft rejection (≥2R; n = 29) or not (n = 198), using Affymetrix Human Gene 1.1 ST microarrays. The cellular composition of the blood samples was inferred from their gene expression profiles. Elastic net classifier panels were then identified using the whole blood gene expression, either unadjusted for cellular composition, adjusted for cellular composition for all cell types, or all but one cell type. Out-of-sample performance of the various models was estimated using stratified 5-fold cross-validation. Results: Best cross-validation performance (AUC = 0.75) was achieved by an NK cell-specific classifier panel. Both cell-adjusted and cell-specific classifiers outperformed those identified using unadjusted whole blood gene expression data. Conclusion: Cell-adjusted/specific biomarker panels outperformed those derived from unadjusted whole blood gene expression. Best performance was achieved by an NK cell-specific biomarker panel. The method presented here is a promising way to incorporate cellular composition in the context of biomarker discovery from gene expression in tissue admixtures.Figure" @default.
- W2614818158 created "2017-05-26" @default.
- W2614818158 creator A5008416148 @default.
- W2614818158 creator A5022174151 @default.
- W2614818158 creator A5022928428 @default.
- W2614818158 creator A5036337799 @default.
- W2614818158 creator A5041792310 @default.
- W2614818158 creator A5044718702 @default.
- W2614818158 creator A5045508594 @default.
- W2614818158 creator A5050643657 @default.
- W2614818158 creator A5058694015 @default.
- W2614818158 creator A5077180290 @default.
- W2614818158 creator A5078399206 @default.
- W2614818158 creator A5079974689 @default.
- W2614818158 creator A5084335083 @default.
- W2614818158 date "2017-05-01" @default.
- W2614818158 modified "2023-10-14" @default.
- W2614818158 title "Investigating Blood-Based, Cell-Specific Biomarkers of Acute Cardiac Allograft Rejection" @default.
- W2614818158 doi "https://doi.org/10.1097/01.tp.0000520331.07917.b7" @default.
- W2614818158 hasPublicationYear "2017" @default.
- W2614818158 type Work @default.
- W2614818158 sameAs 2614818158 @default.
- W2614818158 citedByCount "0" @default.
- W2614818158 crossrefType "journal-article" @default.
- W2614818158 hasAuthorship W2614818158A5008416148 @default.
- W2614818158 hasAuthorship W2614818158A5022174151 @default.
- W2614818158 hasAuthorship W2614818158A5022928428 @default.
- W2614818158 hasAuthorship W2614818158A5036337799 @default.
- W2614818158 hasAuthorship W2614818158A5041792310 @default.
- W2614818158 hasAuthorship W2614818158A5044718702 @default.
- W2614818158 hasAuthorship W2614818158A5045508594 @default.
- W2614818158 hasAuthorship W2614818158A5050643657 @default.
- W2614818158 hasAuthorship W2614818158A5058694015 @default.
- W2614818158 hasAuthorship W2614818158A5077180290 @default.
- W2614818158 hasAuthorship W2614818158A5078399206 @default.
- W2614818158 hasAuthorship W2614818158A5079974689 @default.
- W2614818158 hasAuthorship W2614818158A5084335083 @default.
- W2614818158 hasConcept C104317684 @default.
- W2614818158 hasConcept C126322002 @default.
- W2614818158 hasConcept C142724271 @default.
- W2614818158 hasConcept C150194340 @default.
- W2614818158 hasConcept C18431079 @default.
- W2614818158 hasConcept C186836561 @default.
- W2614818158 hasConcept C2775934546 @default.
- W2614818158 hasConcept C2778849806 @default.
- W2614818158 hasConcept C2781197716 @default.
- W2614818158 hasConcept C2911091166 @default.
- W2614818158 hasConcept C55493867 @default.
- W2614818158 hasConcept C71924100 @default.
- W2614818158 hasConcept C86803240 @default.
- W2614818158 hasConceptScore W2614818158C104317684 @default.
- W2614818158 hasConceptScore W2614818158C126322002 @default.
- W2614818158 hasConceptScore W2614818158C142724271 @default.
- W2614818158 hasConceptScore W2614818158C150194340 @default.
- W2614818158 hasConceptScore W2614818158C18431079 @default.
- W2614818158 hasConceptScore W2614818158C186836561 @default.
- W2614818158 hasConceptScore W2614818158C2775934546 @default.
- W2614818158 hasConceptScore W2614818158C2778849806 @default.
- W2614818158 hasConceptScore W2614818158C2781197716 @default.
- W2614818158 hasConceptScore W2614818158C2911091166 @default.
- W2614818158 hasConceptScore W2614818158C55493867 @default.
- W2614818158 hasConceptScore W2614818158C71924100 @default.
- W2614818158 hasConceptScore W2614818158C86803240 @default.
- W2614818158 hasIssue "5S-3" @default.
- W2614818158 hasLocation W26148181581 @default.
- W2614818158 hasOpenAccess W2614818158 @default.
- W2614818158 hasPrimaryLocation W26148181581 @default.
- W2614818158 hasRelatedWork W198116098 @default.
- W2614818158 hasRelatedWork W1996185163 @default.
- W2614818158 hasRelatedWork W2017047508 @default.
- W2614818158 hasRelatedWork W2039699813 @default.
- W2614818158 hasRelatedWork W2053484432 @default.
- W2614818158 hasRelatedWork W2125826355 @default.
- W2614818158 hasRelatedWork W2183420549 @default.
- W2614818158 hasRelatedWork W23877633 @default.
- W2614818158 hasRelatedWork W2389966295 @default.
- W2614818158 hasRelatedWork W3119668654 @default.
- W2614818158 hasVolume "101" @default.
- W2614818158 isParatext "false" @default.
- W2614818158 isRetracted "false" @default.
- W2614818158 magId "2614818158" @default.
- W2614818158 workType "article" @default.