Matches in SemOpenAlex for { <https://semopenalex.org/work/W2614830534> ?p ?o ?g. }
- W2614830534 endingPage "94" @default.
- W2614830534 startingPage "77" @default.
- W2614830534 abstract "PML nuclear bodies (PML-NBs) are SUMOylation-dependent, highly complex protein assemblies that accumulate in the interchromosomal territories of the cell nucleus. Research of the last two decades revealed that many viruses have evolved effector proteins that modify PML-NBs. This correlates with antagonization of individual PML-NB components which act as host cell restriction factors. The multifunctional immediate-early protein IE1 of human cytomegalovirus directly interacts with the PML protein resulting in a disruption of the dot-like structure of PML-NBs. This review summarizes recent advances on the functional consequences of PML-NB modification by IE1. In particular, we describe that PML exerts a novel co-regulatory role during the interferon response which is abrogated by IE1. Via binding to PML, IE1 is able to compromise both intrinsic antiviral defense mechanisms and classical innate immune responses. These interactions of IE1 with innate host defenses are crucial for the onset of lytic replication and, consequently, may represent promising targets for antiviral strategies." @default.
- W2614830534 created "2017-05-26" @default.
- W2614830534 creator A5026874372 @default.
- W2614830534 creator A5031660301 @default.
- W2614830534 creator A5057025691 @default.
- W2614830534 date "2017-01-01" @default.
- W2614830534 modified "2023-09-24" @default.
- W2614830534 title "The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies" @default.
- W2614830534 cites W143309388 @default.
- W2614830534 cites W1496933864 @default.
- W2614830534 cites W1529629266 @default.
- W2614830534 cites W1545721254 @default.
- W2614830534 cites W1561092615 @default.
- W2614830534 cites W1565293712 @default.
- W2614830534 cites W1587931925 @default.
- W2614830534 cites W1797852794 @default.
- W2614830534 cites W1898584802 @default.
- W2614830534 cites W1933750453 @default.
- W2614830534 cites W1965388358 @default.
- W2614830534 cites W1968537310 @default.
- W2614830534 cites W1970042886 @default.
- W2614830534 cites W1975647987 @default.
- W2614830534 cites W1976732528 @default.
- W2614830534 cites W1979954231 @default.
- W2614830534 cites W1981700185 @default.
- W2614830534 cites W1984733998 @default.
- W2614830534 cites W1988154113 @default.
- W2614830534 cites W1988841577 @default.
- W2614830534 cites W1989142628 @default.
- W2614830534 cites W1989256723 @default.
- W2614830534 cites W2001055572 @default.
- W2614830534 cites W2001599204 @default.
- W2614830534 cites W2001743184 @default.
- W2614830534 cites W2002198253 @default.
- W2614830534 cites W2010569965 @default.
- W2614830534 cites W2011626506 @default.
- W2614830534 cites W2013545866 @default.
- W2614830534 cites W2015197144 @default.
- W2614830534 cites W2020034373 @default.
- W2614830534 cites W2027085235 @default.
- W2614830534 cites W2028067246 @default.
- W2614830534 cites W2032499969 @default.
- W2614830534 cites W2033184490 @default.
- W2614830534 cites W2034116174 @default.
- W2614830534 cites W2037088254 @default.
- W2614830534 cites W2038368872 @default.
- W2614830534 cites W2043025538 @default.
- W2614830534 cites W2044229112 @default.
- W2614830534 cites W2052110360 @default.
- W2614830534 cites W2055107479 @default.
- W2614830534 cites W2063659835 @default.
- W2614830534 cites W2090672652 @default.
- W2614830534 cites W2096242643 @default.
- W2614830534 cites W2099784004 @default.
- W2614830534 cites W2102621085 @default.
- W2614830534 cites W2103231307 @default.
- W2614830534 cites W2106002707 @default.
- W2614830534 cites W2109032735 @default.
- W2614830534 cites W2117505476 @default.
- W2614830534 cites W2117568376 @default.
- W2614830534 cites W2120015511 @default.
- W2614830534 cites W2121059558 @default.
- W2614830534 cites W2121327477 @default.
- W2614830534 cites W2121542842 @default.
- W2614830534 cites W2124778198 @default.
- W2614830534 cites W2126689485 @default.
- W2614830534 cites W2127707170 @default.
- W2614830534 cites W2128974468 @default.
- W2614830534 cites W2128995137 @default.
- W2614830534 cites W2131517280 @default.
- W2614830534 cites W2135463922 @default.
- W2614830534 cites W2136913046 @default.
- W2614830534 cites W2137051059 @default.
- W2614830534 cites W2142888775 @default.
- W2614830534 cites W2149902033 @default.
- W2614830534 cites W2152426521 @default.
- W2614830534 cites W2152442213 @default.
- W2614830534 cites W2152633569 @default.
- W2614830534 cites W2153708119 @default.
- W2614830534 cites W2154124608 @default.
- W2614830534 cites W2154307789 @default.
- W2614830534 cites W2154311445 @default.
- W2614830534 cites W2154747511 @default.
- W2614830534 cites W2156511074 @default.
- W2614830534 cites W2157071824 @default.
- W2614830534 cites W2159624132 @default.
- W2614830534 cites W2160623917 @default.
- W2614830534 cites W2165131038 @default.
- W2614830534 cites W2165991852 @default.
- W2614830534 cites W2166517403 @default.
- W2614830534 cites W2187131173 @default.
- W2614830534 cites W2219488861 @default.
- W2614830534 cites W2230398306 @default.
- W2614830534 cites W2234094683 @default.
- W2614830534 cites W2315689311 @default.
- W2614830534 cites W2330132183 @default.
- W2614830534 cites W2335418691 @default.
- W2614830534 cites W2402259557 @default.