Matches in SemOpenAlex for { <https://semopenalex.org/work/W2614903907> ?p ?o ?g. }
- W2614903907 abstract "The use of live, genetically modified bacteria as delivery vehicles for biologics is of considerable interest scientifically and has attracted significant commercial investment. We have pioneered the use of the commensal gut bacterium Bacteroides ovatus for the oral delivery of therapeutics to the gastrointestinal tract. Here we report on our investigations of the biological safety of engineered B. ovatus bacteria that includes the use of thymineless death as a containment strategy and the potential for the spread of transgenes in vivo in the mammalian gastrointestinal tract. We demonstrate the ability of GM-strains of Bacteroides to survive thymine starvation and overcome it through the exchange of genetic material. We also provide evidence for horizontal gene transfer in the mammalian gastrointestinal tract resulting in transgene-carrying wild type bacteria. These findings sound a strong note of caution on the employment of live genetically modified bacteria for the delivery of biologics." @default.
- W2614903907 created "2017-05-26" @default.
- W2614903907 creator A5021029554 @default.
- W2614903907 creator A5044485257 @default.
- W2614903907 creator A5057650251 @default.
- W2614903907 creator A5072670917 @default.
- W2614903907 date "2017-05-23" @default.
- W2614903907 modified "2023-10-17" @default.
- W2614903907 title "Use of genetically modified bacteria for drug delivery in humans: Revisiting the safety aspect" @default.
- W2614903907 cites W1587483865 @default.
- W2614903907 cites W1625071125 @default.
- W2614903907 cites W1861927956 @default.
- W2614903907 cites W1914752606 @default.
- W2614903907 cites W1923146523 @default.
- W2614903907 cites W1962861052 @default.
- W2614903907 cites W1983725736 @default.
- W2614903907 cites W1985402633 @default.
- W2614903907 cites W2018817395 @default.
- W2614903907 cites W2019262195 @default.
- W2614903907 cites W2086724230 @default.
- W2614903907 cites W2089075037 @default.
- W2614903907 cites W2091587044 @default.
- W2614903907 cites W2092784902 @default.
- W2614903907 cites W2099841321 @default.
- W2614903907 cites W2105822872 @default.
- W2614903907 cites W2107772251 @default.
- W2614903907 cites W2120902911 @default.
- W2614903907 cites W2124374420 @default.
- W2614903907 cites W2139412554 @default.
- W2614903907 cites W2139548528 @default.
- W2614903907 cites W2144447279 @default.
- W2614903907 cites W2147161317 @default.
- W2614903907 cites W2158937196 @default.
- W2614903907 cites W2162623940 @default.
- W2614903907 cites W2168232374 @default.
- W2614903907 cites W2169309064 @default.
- W2614903907 cites W2173004109 @default.
- W2614903907 cites W2407029875 @default.
- W2614903907 cites W2557444342 @default.
- W2614903907 doi "https://doi.org/10.1038/s41598-017-02591-6" @default.
- W2614903907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5442108" @default.
- W2614903907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28536456" @default.
- W2614903907 hasPublicationYear "2017" @default.
- W2614903907 type Work @default.
- W2614903907 sameAs 2614903907 @default.
- W2614903907 citedByCount "31" @default.
- W2614903907 countsByYear W26149039072018 @default.
- W2614903907 countsByYear W26149039072019 @default.
- W2614903907 countsByYear W26149039072020 @default.
- W2614903907 countsByYear W26149039072021 @default.
- W2614903907 countsByYear W26149039072022 @default.
- W2614903907 countsByYear W26149039072023 @default.
- W2614903907 crossrefType "journal-article" @default.
- W2614903907 hasAuthorship W2614903907A5021029554 @default.
- W2614903907 hasAuthorship W2614903907A5044485257 @default.
- W2614903907 hasAuthorship W2614903907A5057650251 @default.
- W2614903907 hasAuthorship W2614903907A5072670917 @default.
- W2614903907 hasBestOaLocation W26149039071 @default.
- W2614903907 hasConcept C102230213 @default.
- W2614903907 hasConcept C104317684 @default.
- W2614903907 hasConcept C150903083 @default.
- W2614903907 hasConcept C2778168646 @default.
- W2614903907 hasConcept C2780512811 @default.
- W2614903907 hasConcept C3019111730 @default.
- W2614903907 hasConcept C51456166 @default.
- W2614903907 hasConcept C523546767 @default.
- W2614903907 hasConcept C54355233 @default.
- W2614903907 hasConcept C55493867 @default.
- W2614903907 hasConcept C86803240 @default.
- W2614903907 hasConcept C89423630 @default.
- W2614903907 hasConceptScore W2614903907C102230213 @default.
- W2614903907 hasConceptScore W2614903907C104317684 @default.
- W2614903907 hasConceptScore W2614903907C150903083 @default.
- W2614903907 hasConceptScore W2614903907C2778168646 @default.
- W2614903907 hasConceptScore W2614903907C2780512811 @default.
- W2614903907 hasConceptScore W2614903907C3019111730 @default.
- W2614903907 hasConceptScore W2614903907C51456166 @default.
- W2614903907 hasConceptScore W2614903907C523546767 @default.
- W2614903907 hasConceptScore W2614903907C54355233 @default.
- W2614903907 hasConceptScore W2614903907C55493867 @default.
- W2614903907 hasConceptScore W2614903907C86803240 @default.
- W2614903907 hasConceptScore W2614903907C89423630 @default.
- W2614903907 hasIssue "1" @default.
- W2614903907 hasLocation W26149039071 @default.
- W2614903907 hasLocation W26149039072 @default.
- W2614903907 hasLocation W26149039073 @default.
- W2614903907 hasLocation W26149039074 @default.
- W2614903907 hasLocation W26149039075 @default.
- W2614903907 hasOpenAccess W2614903907 @default.
- W2614903907 hasPrimaryLocation W26149039071 @default.
- W2614903907 hasRelatedWork W1635063524 @default.
- W2614903907 hasRelatedWork W2109148320 @default.
- W2614903907 hasRelatedWork W2109171635 @default.
- W2614903907 hasRelatedWork W2140966953 @default.
- W2614903907 hasRelatedWork W2347375783 @default.
- W2614903907 hasRelatedWork W2614903907 @default.
- W2614903907 hasRelatedWork W2777320504 @default.
- W2614903907 hasRelatedWork W2961274139 @default.
- W2614903907 hasRelatedWork W3209145189 @default.
- W2614903907 hasRelatedWork W967075409 @default.