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- W2614919679 abstract "Cardiovascular disease remains a leading cause of mortality and morbidity worldwide. Embryonic stem cell-derived cardiomyocytes (ESC-CMs) may offer significant advances in creating in vitro cardiac tissues for disease modeling, drug testing, and elucidating developmental processes; however, the induction of ESCs to a more adult-like CM phenotype remains challenging. In this study, we developed a bioreactor system to employ pulsatile flow (1.48 mL/min), cyclic strain (5%), and extended culture time to improve the maturation of murine and human ESC-CMs. Dynamically-cultured ESC-CMs showed an increased expression of cardiac-associated proteins and genes, cardiac ion channel genes, as well as increased SERCA activity and a Raman fingerprint with the presence of maturation-associated peaks similar to primary CMs. We present a bioreactor platform that can serve as a foundation for the development of human-based cardiac in vitro models to verify drug candidates, and facilitates the study of cardiovascular development and disease." @default.
- W2614919679 created "2017-05-26" @default.
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- W2614919679 date "2017-07-01" @default.
- W2614919679 modified "2023-10-12" @default.
- W2614919679 title "Steps toward Maturation of Embryonic Stem Cell-Derived Cardiomyocytes by Defined Physical Signals" @default.
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- W2614919679 doi "https://doi.org/10.1016/j.stemcr.2017.04.021" @default.
- W2614919679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5511039" @default.
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