FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2614925601> ?p ?o ?g. }

• W2614925601 abstract "Abstract Background The human gut contains approximately 10 14 bacteria, belonging to hundreds of different species. Together, these microbial species form a complex food web that can break down food sources that our own digestive enzymes cannot handle, including complex polysaccharides, producing short chain fatty acids and additional metabolites, e.g. , vitamin K. The diversity of microbial diversity is important for colonic health: Changes in the composition of the microbiota have been associated with inflammatory bowel disease, diabetes, obestity and Crohn’s disease, and make the microbiota more vulnerable to infestation by harmful species, e.g. , Clostridium difficile. To get a grip on the controlling factors of microbial diversity in the gut, we here propose a multi-scale, spatiotemporal dynamic flux-balance analysis model to study the emergence of metabolic diversity in a spatial gut-like, tubular environment. The model features genome-scale metabolic models of microbial populations, resource sharing via extracellular metabolites, and spatial population dynamics and evolution. Results In this model, cross-feeding interactions emerge readily, despite the species’ ability to metabolize sugars autonomously. Interestingly, the community requires cross-feeding for producing a realistic set of short-chain fatty acids from an input of glucose, If we let the composition of the microbial subpopulations change during invasion of adjacent space, a complex and stratifed microbiota evolves, with subspecies specializing on cross-feeding interactions via a mechanism of compensated trait loss. The microbial diversity and stratification collapse if the flux through the gut is enhanced to mimic diarrhea. Conclusions In conclusion, this in silico model is a helpful tool in systems biology to predict and explain the controlling factors of microbial diversity in the gut. It can be extended to include, e.g. , complex food source, and host-microbiota interactions via the gut wall." @default.
• W2614925601 created "2017-05-26" @default.
• W2614925601 creator A5013248006 @default.
• W2614925601 creator A5049980767 @default.
• W2614925601 date "2016-06-20" @default.
• W2614925601 modified "2023-09-26" @default.
• W2614925601 title "Emergence of microbial diversity due to cross-feeding interactions in a spatial model of gut microbial metabolism" @default.
• W2614925601 cites W1804531429 @default.
• W2614925601 cites W1966497610 @default.
• W2614925601 cites W1967190757 @default.
• W2614925601 cites W1980914602 @default.
• W2614925601 cites W1989848555 @default.
• W2614925601 cites W1996529795 @default.
• W2614925601 cites W1998767819 @default.
• W2614925601 cites W2000627531 @default.
• W2614925601 cites W2005609539 @default.
• W2614925601 cites W2009837386 @default.
• W2614925601 cites W2010534192 @default.
• W2614925601 cites W2018745056 @default.
• W2614925601 cites W2019656279 @default.
• W2614925601 cites W2032102844 @default.
• W2614925601 cites W2032230795 @default.
• W2614925601 cites W2037833069 @default.
• W2614925601 cites W2046549547 @default.
• W2614925601 cites W2047195788 @default.
• W2614925601 cites W2048596643 @default.
• W2614925601 cites W2053670382 @default.
• W2614925601 cites W2054087105 @default.
• W2614925601 cites W2054112179 @default.
• W2614925601 cites W2058341998 @default.
• W2614925601 cites W2063810972 @default.
• W2614925601 cites W2076621797 @default.
• W2614925601 cites W2077980171 @default.
• W2614925601 cites W2078355959 @default.
• W2614925601 cites W2087292184 @default.
• W2614925601 cites W2088209062 @default.
• W2614925601 cites W2090925778 @default.
• W2614925601 cites W2096068435 @default.
• W2614925601 cites W2100318643 @default.
• W2614925601 cites W2106800643 @default.
• W2614925601 cites W2108656223 @default.
• W2614925601 cites W2109755334 @default.
• W2614925601 cites W2113382792 @default.
• W2614925601 cites W2118529378 @default.
• W2614925601 cites W2122093325 @default.
• W2614925601 cites W2128898932 @default.
• W2614925601 cites W2129273361 @default.
• W2614925601 cites W2135232490 @default.
• W2614925601 cites W2139607253 @default.
• W2614925601 cites W2143861551 @default.
• W2614925601 cites W2144856591 @default.
• W2614925601 cites W2145336165 @default.
• W2614925601 cites W2147472054 @default.
• W2614925601 cites W2147726663 @default.
• W2614925601 cites W2149573313 @default.
• W2614925601 cites W2150700412 @default.
• W2614925601 cites W2153173272 @default.
• W2614925601 cites W2154393733 @default.
• W2614925601 cites W2155882037 @default.
• W2614925601 cites W2157457604 @default.
• W2614925601 cites W2159379185 @default.
• W2614925601 cites W2159476908 @default.
• W2614925601 cites W2169929899 @default.
• W2614925601 cites W2342540743 @default.
• W2614925601 cites W2949813468 @default.
• W2614925601 cites W4230392683 @default.
• W2614925601 doi "https://doi.org/10.1101/059956" @default.
• W2614925601 hasPublicationYear "2016" @default.
• W2614925601 type Work @default.
• W2614925601 sameAs 2614925601 @default.
• W2614925601 citedByCount "0" @default.
• W2614925601 crossrefType "posted-content" @default.
• W2614925601 hasAuthorship W2614925601A5013248006 @default.
• W2614925601 hasAuthorship W2614925601A5049980767 @default.
• W2614925601 hasBestOaLocation W26149256011 @default.
• W2614925601 hasConcept C101014631 @default.
• W2614925601 hasConcept C104317684 @default.
• W2614925601 hasConcept C143121216 @default.
• W2614925601 hasConcept C15151743 @default.
• W2614925601 hasConcept C199465337 @default.
• W2614925601 hasConcept C2775905019 @default.
• W2614925601 hasConcept C523546767 @default.
• W2614925601 hasConcept C539455810 @default.
• W2614925601 hasConcept C54355233 @default.
• W2614925601 hasConcept C55493867 @default.
• W2614925601 hasConcept C81407943 @default.
• W2614925601 hasConcept C86803240 @default.
• W2614925601 hasConceptScore W2614925601C101014631 @default.
• W2614925601 hasConceptScore W2614925601C104317684 @default.
• W2614925601 hasConceptScore W2614925601C143121216 @default.
• W2614925601 hasConceptScore W2614925601C15151743 @default.
• W2614925601 hasConceptScore W2614925601C199465337 @default.
• W2614925601 hasConceptScore W2614925601C2775905019 @default.
• W2614925601 hasConceptScore W2614925601C523546767 @default.
• W2614925601 hasConceptScore W2614925601C539455810 @default.
• W2614925601 hasConceptScore W2614925601C54355233 @default.
• W2614925601 hasConceptScore W2614925601C55493867 @default.
• W2614925601 hasConceptScore W2614925601C81407943 @default.
• W2614925601 hasConceptScore W2614925601C86803240 @default.
• W2614925601 hasLocation W26149256011 @default.

• next