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- W2614966412 abstract "Abstract RHAMM is hyaluronan- receptor with multiple functions in the cell, RHAMM is involved in proliferation, motility, migration, invasion, mitotic spindle formation in tumour cells. Therefore, RHAMM could be a relevant target for molecular targeted therapies against tumors.The role of RHAMM-target peptides in inhibition invasion for preventing breast cancer has not yet been investigated. Base on this, we analyzed the RHAMM-target peptides for their therapeutic activity against breast cancer cells. In the present study, we examined the effect of RHAMM-target peptides on the invasion of breast cancer cells (MDAMB- 231), using confocal microscopy. We shown that RHAMM-target peptides decreased formation of invadopodia of breast cancer cells. The treatment of breast cancer cells by RHAMM -target peptides inhibited the invasion up to 99 %. Additionally, RHAMM-target peptides induced the morphological changes of of breast cancer cells. Therefore, based on these results, we can conclude that RHAMM-target peptides may be potential anti-cancer agents." @default.
- W2614966412 created "2017-05-26" @default.
- W2614966412 creator A5054090264 @default.
- W2614966412 date "2017-05-09" @default.
- W2614966412 modified "2023-09-25" @default.
- W2614966412 title "RHAMM-target peptides inhibit invasion of breast cancer cells" @default.
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- W2614966412 doi "https://doi.org/10.24190/issn2564-615x/2017/02.05" @default.
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