Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615029715> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2615029715 endingPage "S4" @default.
- W2615029715 startingPage "S4" @default.
- W2615029715 abstract "Backgound: Recent studies have shown that lncRNAs play crucial role in the innate immune response and T cell development, activation, and differentiation. However, little is known how they function in T cell subset polarization, such as regulatory T cells (Treg) and Th17. We reported lncRNAs profile in murine heart allograft rejection, provided differentially expressed lncRNAs.[1] Methods: Naive CD4+ CD25- CD62Lhi T cells were purified from the splenocytes of B6.Cg-Foxp3tm2Tch/J (Foxp3/GFP) transgenic mice. Regulatory T cell culture was conducted as previous. lncRNAs expression was test by qPCR. Results: Observing the various expression in lncRNA microarray results, the expression of lncRNA-AK005641 was downregulated in murine heart allograft. Next we desired to further know the relevance of lncRNAs in various lymphocyte subsets. CD4+Foxp3+ T cells, regarded as nTreg, were sorted from Foxp3/GFP transgenic mice splenocytes. The expression of lncRNA-AK005641 was significantly upregulated in nTreg(GFP+) comparing with CD4+Foxp3- T cells (GFP-). The expression of lncRNA-AK005641 was significantly upregulated in iTreg comparing with CD4+Foxp3- T cells. Subsequently, iTreg and Th0 polarization condition culture were performed. In the period from naïve T cell differentiated into iTreg, the expression of lncRNA-AK005641 was upregulated when compared with Th0 culture in each time point. On day 3, the CD4+ Foxp3+ T cells(GFP+) and CD4+ Foxp3- (GFP-)were sorted from iTreg culture. The expression of AK005641 was significantly upregulated in iTreg. Taken together, the result indicated that lncRNA-AK005641 had a high expression in both nTreg and iTreg.FigureFigureConclusions: Our results provide a preliminary profile of lncRNA–AK005641 that may regulate immune response, especially in Tregs differentiation. We will further analyze the expression of lncRNA–AK005641 in transplant recipients’ PBMC, owing to test the relevance between lncRNA–AK005641 and clinical rejection or tolerance. References: 1. Gu G, et al. Transplantation. 2017 Jan;101(1):83–91." @default.
- W2615029715 created "2017-05-26" @default.
- W2615029715 creator A5001291004 @default.
- W2615029715 creator A5007147243 @default.
- W2615029715 creator A5013289800 @default.
- W2615029715 creator A5024094461 @default.
- W2615029715 creator A5042706833 @default.
- W2615029715 creator A5061481279 @default.
- W2615029715 creator A5064024990 @default.
- W2615029715 date "2017-05-01" @default.
- W2615029715 modified "2023-09-26" @default.
- W2615029715 title "Expression of lncRNA-AK005641 in Murine CD4+FOXP3+Treg and iTreg Differentiation" @default.
- W2615029715 doi "https://doi.org/10.1097/01.tp.0000520296.28521.7c" @default.
- W2615029715 hasPublicationYear "2017" @default.
- W2615029715 type Work @default.
- W2615029715 sameAs 2615029715 @default.
- W2615029715 citedByCount "1" @default.
- W2615029715 countsByYear W26150297152019 @default.
- W2615029715 crossrefType "journal-article" @default.
- W2615029715 hasAuthorship W2615029715A5001291004 @default.
- W2615029715 hasAuthorship W2615029715A5007147243 @default.
- W2615029715 hasAuthorship W2615029715A5013289800 @default.
- W2615029715 hasAuthorship W2615029715A5024094461 @default.
- W2615029715 hasAuthorship W2615029715A5042706833 @default.
- W2615029715 hasAuthorship W2615029715A5061481279 @default.
- W2615029715 hasAuthorship W2615029715A5064024990 @default.
- W2615029715 hasConcept C102230213 @default.
- W2615029715 hasConcept C104317684 @default.
- W2615029715 hasConcept C127561419 @default.
- W2615029715 hasConcept C148738053 @default.
- W2615029715 hasConcept C153911025 @default.
- W2615029715 hasConcept C203014093 @default.
- W2615029715 hasConcept C2776090121 @default.
- W2615029715 hasConcept C2779727006 @default.
- W2615029715 hasConcept C54355233 @default.
- W2615029715 hasConcept C79484868 @default.
- W2615029715 hasConcept C86803240 @default.
- W2615029715 hasConcept C8891405 @default.
- W2615029715 hasConcept C95444343 @default.
- W2615029715 hasConceptScore W2615029715C102230213 @default.
- W2615029715 hasConceptScore W2615029715C104317684 @default.
- W2615029715 hasConceptScore W2615029715C127561419 @default.
- W2615029715 hasConceptScore W2615029715C148738053 @default.
- W2615029715 hasConceptScore W2615029715C153911025 @default.
- W2615029715 hasConceptScore W2615029715C203014093 @default.
- W2615029715 hasConceptScore W2615029715C2776090121 @default.
- W2615029715 hasConceptScore W2615029715C2779727006 @default.
- W2615029715 hasConceptScore W2615029715C54355233 @default.
- W2615029715 hasConceptScore W2615029715C79484868 @default.
- W2615029715 hasConceptScore W2615029715C86803240 @default.
- W2615029715 hasConceptScore W2615029715C8891405 @default.
- W2615029715 hasConceptScore W2615029715C95444343 @default.
- W2615029715 hasIssue "5S-3" @default.
- W2615029715 hasLocation W26150297151 @default.
- W2615029715 hasOpenAccess W2615029715 @default.
- W2615029715 hasPrimaryLocation W26150297151 @default.
- W2615029715 hasRelatedWork W1992037894 @default.
- W2615029715 hasRelatedWork W2038833571 @default.
- W2615029715 hasRelatedWork W2075628498 @default.
- W2615029715 hasRelatedWork W2103296897 @default.
- W2615029715 hasRelatedWork W2153070516 @default.
- W2615029715 hasRelatedWork W2366649094 @default.
- W2615029715 hasRelatedWork W2388380992 @default.
- W2615029715 hasRelatedWork W2418194605 @default.
- W2615029715 hasRelatedWork W2890210959 @default.
- W2615029715 hasRelatedWork W3031955394 @default.
- W2615029715 hasVolume "101" @default.
- W2615029715 isParatext "false" @default.
- W2615029715 isRetracted "false" @default.
- W2615029715 magId "2615029715" @default.
- W2615029715 workType "article" @default.