FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615031298> ?p ?o ?g. }

• W2615031298 endingPage "5585" @default.
• W2615031298 startingPage "5577" @default.
• W2615031298 abstract "Transcription-export complex 2 (TREX-2, or THSC) facilitates localization of actively transcribing genes such as GAL1 to the nuclear periphery, contributes to the generation of export-competent mRNPs and influences gene expression through interactions with Mediator. TREX-2 is based on a Sac3 scaffold to which Thp1, Sem1, Cdc31 and Sus1 bind and consists of three modules: the N-region (Sac3∼1-100), which binds mRNA export factor Mex67:Mtr2; the M-region, in which Thp1 and Sem1 bind to Sac3∼100-550; and the CID region in which Cdc31 and two Sus1 chains bind to Sac3∼720-805. Although the M-region of Sac3 was originally thought to encompass residues ∼250-550, we report here the 2.3Å resolution crystal structure of a complex containing Sac3 residues 60-550 that indicates that the TPR-like repeats of the M-region extend to residue 137 and that residues 90-125 form a novel loop that links Sac3 to Thp1. These new structural elements are important for growth and mRNA export in vivo. Although deleting Sac3 residues 1-90 produced a wild-type phenotype, deletion of the loop as well generated growth defects at 37°C, whereas the deletion of residues 1-250 impaired mRNA export and also generated longer lag times when glucose or raffinose was replaced by galactose as the carbon source." @default.
• W2615031298 created "2017-05-26" @default.
• W2615031298 creator A5001482627 @default.
• W2615031298 creator A5023472656 @default.
• W2615031298 creator A5055816508 @default.
• W2615031298 date "2017-03-15" @default.
• W2615031298 modified "2023-09-27" @default.
• W2615031298 title "Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex" @default.
• W2615031298 cites W1585642793 @default.
• W2615031298 cites W1936611779 @default.
• W2615031298 cites W1975620486 @default.
• W2615031298 cites W1981329233 @default.
• W2615031298 cites W1989644696 @default.
• W2615031298 cites W2003907050 @default.
• W2615031298 cites W2004377868 @default.
• W2615031298 cites W2009018280 @default.
• W2615031298 cites W2019923915 @default.
• W2615031298 cites W2027456056 @default.
• W2615031298 cites W2043375872 @default.
• W2615031298 cites W2058402081 @default.
• W2615031298 cites W2065677302 @default.
• W2615031298 cites W2079255995 @default.
• W2615031298 cites W2079815614 @default.
• W2615031298 cites W2084389717 @default.
• W2615031298 cites W2084820754 @default.
• W2615031298 cites W2096580557 @default.
• W2615031298 cites W2103573935 @default.
• W2615031298 cites W2107996465 @default.
• W2615031298 cites W2109845157 @default.
• W2615031298 cites W2110808180 @default.
• W2615031298 cites W2116114189 @default.
• W2615031298 cites W2124026197 @default.
• W2615031298 cites W2136030861 @default.
• W2615031298 cites W2140983210 @default.
• W2615031298 cites W2147543837 @default.
• W2615031298 cites W2151683280 @default.
• W2615031298 cites W2154714625 @default.
• W2615031298 cites W2156571424 @default.
• W2615031298 cites W2180229411 @default.
• W2615031298 cites W2193922719 @default.
• W2615031298 cites W2194394091 @default.
• W2615031298 cites W2410703444 @default.
• W2615031298 cites W2489511141 @default.
• W2615031298 cites W4210476737 @default.
• W2615031298 cites W4210675630 @default.
• W2615031298 cites W4248872320 @default.
• W2615031298 doi "https://doi.org/10.1093/nar/gkx158" @default.
• W2615031298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5435946" @default.
• W2615031298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28334829" @default.
• W2615031298 hasPublicationYear "2017" @default.
• W2615031298 type Work @default.
• W2615031298 sameAs 2615031298 @default.
• W2615031298 citedByCount "6" @default.
• W2615031298 countsByYear W26150312982019 @default.
• W2615031298 countsByYear W26150312982020 @default.
• W2615031298 countsByYear W26150312982021 @default.
• W2615031298 countsByYear W26150312982022 @default.
• W2615031298 crossrefType "journal-article" @default.
• W2615031298 hasAuthorship W2615031298A5001482627 @default.
• W2615031298 hasAuthorship W2615031298A5023472656 @default.
• W2615031298 hasAuthorship W2615031298A5055816508 @default.
• W2615031298 hasBestOaLocation W26150312981 @default.
• W2615031298 hasConcept C104317684 @default.
• W2615031298 hasConcept C105580179 @default.
• W2615031298 hasConcept C126725582 @default.
• W2615031298 hasConcept C138885662 @default.
• W2615031298 hasConcept C153911025 @default.
• W2615031298 hasConcept C179926584 @default.
• W2615031298 hasConcept C190062978 @default.
• W2615031298 hasConcept C2777336224 @default.
• W2615031298 hasConcept C2777576037 @default.
• W2615031298 hasConcept C2780114586 @default.
• W2615031298 hasConcept C2910135453 @default.
• W2615031298 hasConcept C41895202 @default.
• W2615031298 hasConcept C54355233 @default.
• W2615031298 hasConcept C552990157 @default.
• W2615031298 hasConcept C59157529 @default.
• W2615031298 hasConcept C67705224 @default.
• W2615031298 hasConcept C86803240 @default.
• W2615031298 hasConceptScore W2615031298C104317684 @default.
• W2615031298 hasConceptScore W2615031298C105580179 @default.
• W2615031298 hasConceptScore W2615031298C126725582 @default.
• W2615031298 hasConceptScore W2615031298C138885662 @default.
• W2615031298 hasConceptScore W2615031298C153911025 @default.
• W2615031298 hasConceptScore W2615031298C179926584 @default.
• W2615031298 hasConceptScore W2615031298C190062978 @default.
• W2615031298 hasConceptScore W2615031298C2777336224 @default.
• W2615031298 hasConceptScore W2615031298C2777576037 @default.
• W2615031298 hasConceptScore W2615031298C2780114586 @default.
• W2615031298 hasConceptScore W2615031298C2910135453 @default.
• W2615031298 hasConceptScore W2615031298C41895202 @default.
• W2615031298 hasConceptScore W2615031298C54355233 @default.
• W2615031298 hasConceptScore W2615031298C552990157 @default.
• W2615031298 hasConceptScore W2615031298C59157529 @default.
• W2615031298 hasConceptScore W2615031298C67705224 @default.
• W2615031298 hasConceptScore W2615031298C86803240 @default.
• W2615031298 hasIssue "9" @default.
• W2615031298 hasLocation W26150312981 @default.

• next