FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615031550> ?p ?o ?g. }

• W2615031550 endingPage "S25" @default.
• W2615031550 startingPage "S25" @default.
• W2615031550 abstract "Introduction: HLA-G is a non-classical HLA molecule and better known to play a crucial role in allogenic situations such as pregnancy or allograft transplantation. The higher expression of this molecule is related with better outcome in allograft transplantation. Objective: The aim of the study was to investigate the role of HLA-G in North Indian patients undergoing renal transplantation. Materials and Methods: A total of 39 recipient-donor pairs were enrolled in the study (Department of Nephrology/Surgery) and results were compared with 50 healthy controls. Of the 39 recipient-donor pairs enrolled, 11 subjects experienced graft rejection episodes. HLA-G exon 8- 14 bp INDEL polymorphism was tested by PCR-SSP and sequencing. Serum soluble HLA-G levels (pre-transplant, day 15, 30, 60, and 90) were measured using ELISA. Results: The distribution of HLA-G 14 bp genotype among the healthy controls was exon 8-14 bp ins/del-46%, del/del-24% and ins/ins-30%. Among the recipients, the genotype data was evaluated on segregation of recipients in rejection and non-rejection groups. In non-rejection group, higher percentage of recipients carried ins/ins genotype as compared to the rejection group (32.1% vs 20% respectively). 60% of recipients in rejection and 46.4% of recipients in non-rejection group carried the heterozygous genotype. Distribution of del/del genotype was similar in both groups. The median sHLA-G level was 31.7 U/ml in healthy controls. sHLA-G levels were higher in the individuals with ins/ins genotype in comparison to del/del or ins/del genotype. It was observed that the sHLA-G levels were significantly high in renal transplant recipients when compared with healthy controls. sHLA-G levels were lower in the recipient cohort which experienced a rejection episode (median-105.4 U/ml) as compared to recipients maintaining well-functioning grafts (median- 260.4 U/ml). In the group with well-functioning graft, the sHLA-G levels were better maintained throughout the post-transplant period, whereas in the rejection group, the sHLA-G levels improved only after anti-rejection therapy, however, the levels were lower than well-functioning group. Discussion: It is evident that HLA-G 3’UTR genotyping and serial monitoring of sHLA-G levels in serum/plasma may be useful tests for predicting any adverse event like rejection. All India Institute of Medical Sciences, New Delhi. Indian Council of Medical Research, India." @default.
• W2615031550 created "2017-05-26" @default.
• W2615031550 creator A5037448197 @default.
• W2615031550 creator A5078400198 @default.
• W2615031550 creator A5081889503 @default.
• W2615031550 creator A5081983422 @default.
• W2615031550 creator A5082859315 @default.
• W2615031550 date "2017-05-01" @default.
• W2615031550 modified "2023-10-03" @default.
• W2615031550 title "Expression of sHLA-G Identifies Favorable Outcome in Renal Transplant Recipients" @default.
• W2615031550 doi "https://doi.org/10.1097/01.tp.0000520334.92669.aa" @default.
• W2615031550 hasPublicationYear "2017" @default.
• W2615031550 type Work @default.
• W2615031550 sameAs 2615031550 @default.
• W2615031550 citedByCount "1" @default.
• W2615031550 countsByYear W26150315502020 @default.
• W2615031550 crossrefType "journal-article" @default.
• W2615031550 hasAuthorship W2615031550A5037448197 @default.
• W2615031550 hasAuthorship W2615031550A5078400198 @default.
• W2615031550 hasAuthorship W2615031550A5081889503 @default.
• W2615031550 hasAuthorship W2615031550A5081983422 @default.
• W2615031550 hasAuthorship W2615031550A5082859315 @default.
• W2615031550 hasConcept C104317684 @default.
• W2615031550 hasConcept C119054055 @default.
• W2615031550 hasConcept C126322002 @default.
• W2615031550 hasConcept C135763542 @default.
• W2615031550 hasConcept C147483822 @default.
• W2615031550 hasConcept C153209595 @default.
• W2615031550 hasConcept C188280979 @default.
• W2615031550 hasConcept C203014093 @default.
• W2615031550 hasConcept C2780303639 @default.
• W2615031550 hasConcept C2911091166 @default.
• W2615031550 hasConcept C54355233 @default.
• W2615031550 hasConcept C71924100 @default.
• W2615031550 hasConcept C86803240 @default.
• W2615031550 hasConcept C90924648 @default.
• W2615031550 hasConceptScore W2615031550C104317684 @default.
• W2615031550 hasConceptScore W2615031550C119054055 @default.
• W2615031550 hasConceptScore W2615031550C126322002 @default.
• W2615031550 hasConceptScore W2615031550C135763542 @default.
• W2615031550 hasConceptScore W2615031550C147483822 @default.
• W2615031550 hasConceptScore W2615031550C153209595 @default.
• W2615031550 hasConceptScore W2615031550C188280979 @default.
• W2615031550 hasConceptScore W2615031550C203014093 @default.
• W2615031550 hasConceptScore W2615031550C2780303639 @default.
• W2615031550 hasConceptScore W2615031550C2911091166 @default.
• W2615031550 hasConceptScore W2615031550C54355233 @default.
• W2615031550 hasConceptScore W2615031550C71924100 @default.
• W2615031550 hasConceptScore W2615031550C86803240 @default.
• W2615031550 hasConceptScore W2615031550C90924648 @default.
• W2615031550 hasIssue "5S-3" @default.
• W2615031550 hasLocation W26150315501 @default.
• W2615031550 hasOpenAccess W2615031550 @default.
• W2615031550 hasPrimaryLocation W26150315501 @default.
• W2615031550 hasRelatedWork W1525623461 @default.
• W2615031550 hasRelatedWork W1944774975 @default.
• W2615031550 hasRelatedWork W1997456581 @default.
• W2615031550 hasRelatedWork W2076534196 @default.
• W2615031550 hasRelatedWork W2403637593 @default.
• W2615031550 hasRelatedWork W2606408901 @default.
• W2615031550 hasRelatedWork W2942801107 @default.
• W2615031550 hasRelatedWork W2992668836 @default.
• W2615031550 hasRelatedWork W3196213138 @default.
• W2615031550 hasRelatedWork W4226354421 @default.
• W2615031550 hasVolume "101" @default.
• W2615031550 isParatext "false" @default.
• W2615031550 isRetracted "false" @default.
• W2615031550 magId "2615031550" @default.
• W2615031550 workType "article" @default.