Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615141540> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2615141540 endingPage "S43" @default.
- W2615141540 startingPage "S43" @default.
- W2615141540 abstract "Introduction: Activation of PARP is a critical factor in the pathogenesis of various inflammatory and fibrotic process. Thus, we aimed to show the integral of PARP in the inflammatory process of glomeruli and the development of transplant glomerulopathy (TG). Methods: Biopsies of 82 patients with antibody-mediated rejection were included to study. PARP, α-SMA, and TNF-α, expression of glomeruli studied. The mean number of neutrophil, macrophage, and lymphocyte infiltration per glomerulus evaluated. The degree of the peritubular capillary (PTC) inflammation and the presence of neutrophil and macrophage in PTCs investigated. PTC C4d, PARP, and HLA-DR expression graded. The decreasing intensity of PTC HLA-DR (PTC-DR) expression accepted as the increasing degree of the destruction of PTC’s. Follow-up biopsies analyzed for the development of transplant glomerulopathy. Results: Of 82 recipients, only 40 showed TG. The time of the development of TG decreased with increasing degree of PTC neutrophil and macrophage infiltration, PTC inflammation, intraglomerular macrophage, and neutrophil infiltration (p < 0.001). TG development is increased with increasing amount of C4d expression and with decreasing degree of PTC-DR expression (p < 0.001). TG was found earlier in recipients who had a higher degree of glomerular, and PTC PARP expression (p < 0.001). Also, patients with a greater degree of glomerular PARP expression showed a higher amount of glomerular α-SMA and TNF-α expression. The intensity of the glomerular and PTC macrophage and neutrophil infiltration increases with increasing amount of glomerular and PTC PARP expression (p < 0.001). The 5-year graft survival was 78% and 15% for recipients with negative and positive glomerular PARP expression respectively (p < 0.001). Also, the5-year survival was 84%, 41% and %0 for patients with grade1, 2 and 3 PTC PARP expression respectively (p < 0.001). Conclusion: Increased PARP activation both in glomeruli and PTCs leads to early TG and early graft loss. Thus, it will be beneficial to use PARP inhibitor drugs in recipients with a high risk of transplant glomerulopathy." @default.
- W2615141540 created "2017-05-26" @default.
- W2615141540 creator A5010311340 @default.
- W2615141540 creator A5016067432 @default.
- W2615141540 creator A5017994509 @default.
- W2615141540 creator A5023853920 @default.
- W2615141540 creator A5056979219 @default.
- W2615141540 date "2017-05-01" @default.
- W2615141540 modified "2023-10-06" @default.
- W2615141540 title "Development of Transplant Glomerulopathy in Recipients With Antibody Mediated Rejection" @default.
- W2615141540 doi "https://doi.org/10.1097/01.tp.0000520364.45828.da" @default.
- W2615141540 hasPublicationYear "2017" @default.
- W2615141540 type Work @default.
- W2615141540 sameAs 2615141540 @default.
- W2615141540 citedByCount "0" @default.
- W2615141540 crossrefType "journal-article" @default.
- W2615141540 hasAuthorship W2615141540A5010311340 @default.
- W2615141540 hasAuthorship W2615141540A5016067432 @default.
- W2615141540 hasAuthorship W2615141540A5017994509 @default.
- W2615141540 hasAuthorship W2615141540A5023853920 @default.
- W2615141540 hasAuthorship W2615141540A5056979219 @default.
- W2615141540 hasConcept C121332964 @default.
- W2615141540 hasConcept C126322002 @default.
- W2615141540 hasConcept C142724271 @default.
- W2615141540 hasConcept C153400128 @default.
- W2615141540 hasConcept C185592680 @default.
- W2615141540 hasConcept C202751555 @default.
- W2615141540 hasConcept C203014093 @default.
- W2615141540 hasConcept C2776914184 @default.
- W2615141540 hasConcept C2779244956 @default.
- W2615141540 hasConcept C2780091579 @default.
- W2615141540 hasConcept C2780199430 @default.
- W2615141540 hasConcept C2780368995 @default.
- W2615141540 hasConcept C2780829873 @default.
- W2615141540 hasConcept C2780942790 @default.
- W2615141540 hasConcept C2911091166 @default.
- W2615141540 hasConcept C55493867 @default.
- W2615141540 hasConcept C71924100 @default.
- W2615141540 hasConcept C97355855 @default.
- W2615141540 hasConceptScore W2615141540C121332964 @default.
- W2615141540 hasConceptScore W2615141540C126322002 @default.
- W2615141540 hasConceptScore W2615141540C142724271 @default.
- W2615141540 hasConceptScore W2615141540C153400128 @default.
- W2615141540 hasConceptScore W2615141540C185592680 @default.
- W2615141540 hasConceptScore W2615141540C202751555 @default.
- W2615141540 hasConceptScore W2615141540C203014093 @default.
- W2615141540 hasConceptScore W2615141540C2776914184 @default.
- W2615141540 hasConceptScore W2615141540C2779244956 @default.
- W2615141540 hasConceptScore W2615141540C2780091579 @default.
- W2615141540 hasConceptScore W2615141540C2780199430 @default.
- W2615141540 hasConceptScore W2615141540C2780368995 @default.
- W2615141540 hasConceptScore W2615141540C2780829873 @default.
- W2615141540 hasConceptScore W2615141540C2780942790 @default.
- W2615141540 hasConceptScore W2615141540C2911091166 @default.
- W2615141540 hasConceptScore W2615141540C55493867 @default.
- W2615141540 hasConceptScore W2615141540C71924100 @default.
- W2615141540 hasConceptScore W2615141540C97355855 @default.
- W2615141540 hasIssue "5S-3" @default.
- W2615141540 hasLocation W26151415401 @default.
- W2615141540 hasOpenAccess W2615141540 @default.
- W2615141540 hasPrimaryLocation W26151415401 @default.
- W2615141540 hasRelatedWork W162192359 @default.
- W2615141540 hasRelatedWork W2038666717 @default.
- W2615141540 hasRelatedWork W2163766916 @default.
- W2615141540 hasRelatedWork W2186316345 @default.
- W2615141540 hasRelatedWork W2214091569 @default.
- W2615141540 hasRelatedWork W2313447129 @default.
- W2615141540 hasRelatedWork W4241335203 @default.
- W2615141540 hasRelatedWork W4248746885 @default.
- W2615141540 hasRelatedWork W825605603 @default.
- W2615141540 hasRelatedWork W93566195 @default.
- W2615141540 hasVolume "101" @default.
- W2615141540 isParatext "false" @default.
- W2615141540 isRetracted "false" @default.
- W2615141540 magId "2615141540" @default.
- W2615141540 workType "article" @default.