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• W2615165013 abstract "Programmed death ligand 1 (PD-L1) is highly expressed in many cancers. We investigated the expression of PD-L1 and its relationship with vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 and KI-67 expression in 64 patients with primary glioma. The expression rate of PD-L1 in glioma patients was 78.12%. PD-L1 levels correlated with the tumor grade (p = 0.013), VEGF status (p = 0.002) and KI-67 status (p = 0.002). In addition, PD-L1 levels correlated positively with VEGF (r = 0.314, p = 0.011) and KI-67 (r = 0.391, p = 0.001) levels when the data were treated as continuous variables. This is the first report suggesting that PD-L1 is important for glioma angiogenesis and proliferation. Thus, further research should be conducted to assess the combination of targeted VEGF therapy and anti-PD-L1 immunotherapy for the treatment of glioma." @default.
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• W2615165013 date "2017-05-17" @default.
• W2615165013 modified "2023-10-13" @default.
• W2615165013 title "Relationship between expression of PD-L1 and tumor angiogenesis, proliferation, and invasion in glioma" @default.
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• W2615165013 doi "https://doi.org/10.18632/oncotarget.17922" @default.
• W2615165013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5564800" @default.
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