Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615170185> ?p ?o ?g. }
- W2615170185 endingPage "175909141770872" @default.
- W2615170185 startingPage "175909141770872" @default.
- W2615170185 abstract "New neurons are born throughout the life of mammals in germinal zones of the brain known as neurogenic niches: the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus of the hippocampus. These niches contain a subpopulation of cells known as adult neural progenitor cells (aNPCs), which self-renew and give rise to new neurons and glia. aNPCs are regulated by many factors present in the niche, including the extracellular matrix (ECM). We show that the neuropeptide PACAP (pituitary adenylate cyclase-activating polypeptide) affects subventricular zone-derived aNPCs by increasing their surface adhesion. Gene array and reconstitution assays indicate that this effect can be attributed to the regulation of ECM components and ECM-modifying enzymes in aNPCs by PACAP. Our work suggests that PACAP regulates a bidirectional interaction between the aNPCs and their niche: PACAP modifies ECM production and remodeling, in turn the ECM regulates progenitor cell adherence. We speculate that PACAP may in this manner help restrict adult neural progenitors to the stem cell niche in vivo, with potential significance for aNPC function in physiological and pathological states." @default.
- W2615170185 created "2017-05-26" @default.
- W2615170185 creator A5005855723 @default.
- W2615170185 creator A5030527919 @default.
- W2615170185 creator A5063871500 @default.
- W2615170185 creator A5064960085 @default.
- W2615170185 creator A5072668850 @default.
- W2615170185 date "2017-05-19" @default.
- W2615170185 modified "2023-09-27" @default.
- W2615170185 title "PACAP Promotes Matrix-Driven Adhesion of Cultured Adult Murine Neural Progenitors" @default.
- W2615170185 cites W1224329310 @default.
- W2615170185 cites W1500158856 @default.
- W2615170185 cites W1510029487 @default.
- W2615170185 cites W1526723238 @default.
- W2615170185 cites W1579609657 @default.
- W2615170185 cites W1633153776 @default.
- W2615170185 cites W1764117570 @default.
- W2615170185 cites W1811114279 @default.
- W2615170185 cites W1859730138 @default.
- W2615170185 cites W1918494965 @default.
- W2615170185 cites W1939198520 @default.
- W2615170185 cites W1967011241 @default.
- W2615170185 cites W1968152111 @default.
- W2615170185 cites W1968840425 @default.
- W2615170185 cites W1977667876 @default.
- W2615170185 cites W1990422815 @default.
- W2615170185 cites W1995319712 @default.
- W2615170185 cites W1995582623 @default.
- W2615170185 cites W1996885352 @default.
- W2615170185 cites W2000029352 @default.
- W2615170185 cites W2000321229 @default.
- W2615170185 cites W2004590336 @default.
- W2615170185 cites W2005783196 @default.
- W2615170185 cites W2007242343 @default.
- W2615170185 cites W2010842608 @default.
- W2615170185 cites W2012305618 @default.
- W2615170185 cites W2012901548 @default.
- W2615170185 cites W2013362755 @default.
- W2615170185 cites W2013721472 @default.
- W2615170185 cites W2020447498 @default.
- W2615170185 cites W2021766835 @default.
- W2615170185 cites W2023331971 @default.
- W2615170185 cites W2026393786 @default.
- W2615170185 cites W2028856874 @default.
- W2615170185 cites W2029589343 @default.
- W2615170185 cites W2032490809 @default.
- W2615170185 cites W2032922495 @default.
- W2615170185 cites W2034346264 @default.
- W2615170185 cites W2036471756 @default.
- W2615170185 cites W2036857715 @default.
- W2615170185 cites W2037220592 @default.
- W2615170185 cites W2040279612 @default.
- W2615170185 cites W2045707010 @default.
- W2615170185 cites W2046521512 @default.
- W2615170185 cites W2047967176 @default.
- W2615170185 cites W2053911175 @default.
- W2615170185 cites W2063162158 @default.
- W2615170185 cites W2065323453 @default.
- W2615170185 cites W2067624621 @default.
- W2615170185 cites W2071435286 @default.
- W2615170185 cites W2072469132 @default.
- W2615170185 cites W2072621156 @default.
- W2615170185 cites W2082372528 @default.
- W2615170185 cites W2083544543 @default.
- W2615170185 cites W2088836474 @default.
- W2615170185 cites W2091611675 @default.
- W2615170185 cites W2092769431 @default.
- W2615170185 cites W2103926052 @default.
- W2615170185 cites W2109542855 @default.
- W2615170185 cites W2126695938 @default.
- W2615170185 cites W2133465414 @default.
- W2615170185 cites W2146839421 @default.
- W2615170185 cites W2149380656 @default.
- W2615170185 cites W2151875422 @default.
- W2615170185 cites W2155533668 @default.
- W2615170185 cites W2158217645 @default.
- W2615170185 cites W2160023163 @default.
- W2615170185 cites W2164425920 @default.
- W2615170185 cites W2165326716 @default.
- W2615170185 cites W2168618504 @default.
- W2615170185 cites W2169401102 @default.
- W2615170185 cites W2346037068 @default.
- W2615170185 cites W2419688738 @default.
- W2615170185 cites W2505265915 @default.
- W2615170185 cites W2582576545 @default.
- W2615170185 cites W51113485 @default.
- W2615170185 cites W4213393686 @default.
- W2615170185 doi "https://doi.org/10.1177/1759091417708720" @default.
- W2615170185 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5439654" @default.
- W2615170185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28523979" @default.
- W2615170185 hasPublicationYear "2017" @default.
- W2615170185 type Work @default.
- W2615170185 sameAs 2615170185 @default.
- W2615170185 citedByCount "4" @default.
- W2615170185 countsByYear W26151701852018 @default.
- W2615170185 countsByYear W26151701852019 @default.
- W2615170185 countsByYear W26151701852021 @default.
- W2615170185 crossrefType "journal-article" @default.