Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615202319> ?p ?o ?g. }
- W2615202319 endingPage "2836" @default.
- W2615202319 startingPage "2823" @default.
- W2615202319 abstract "Vascular smooth muscle cells (VSMCs) switch to macrophage-like cells after cholesterol loading, and this change may play an important role in the progression of atherosclerosis. C1q/TNF-related protein 9 (CTRP9) is a recently discovered adipokine that has been shown to have beneficial effects on glucose metabolism and vascular function, particularly in regard to cardiovascular disease. The question of whether CTRP9 can protect VSMCs from cholesterol damage has not been addressed. In this study, the impact of CTRP9 on cholesterol-damaged VSMCs was observed. Our data show that in cholesterol-treated VSMCs, CTRP9 significantly reversed the cholesterol-induced increases in pro-inflammatory factor secretion, monocyte adhesion, cholesterol uptake and expression of the macrophage marker CD68. Meanwhile, CTRP9 prevented the cholesterol-induced activation of the TLR4-MyD88-p65 pathway and upregulated the expression of proteins important for cholesterol efflux. Mechanistically, as siRNA-induced selective gene ablation of AMPKα1 abolished these effects of CTRP9, we concluded that CTRP9 achieves these protective effects in VSMCs through the AMP-dependent kinase (AMPK) pathway." @default.
- W2615202319 created "2017-05-26" @default.
- W2615202319 creator A5018728349 @default.
- W2615202319 creator A5029579774 @default.
- W2615202319 creator A5049043613 @default.
- W2615202319 creator A5051221401 @default.
- W2615202319 creator A5059314796 @default.
- W2615202319 creator A5059712495 @default.
- W2615202319 creator A5071037763 @default.
- W2615202319 creator A5078135774 @default.
- W2615202319 creator A5078863108 @default.
- W2615202319 creator A5085028455 @default.
- W2615202319 date "2017-05-19" @default.
- W2615202319 modified "2023-10-02" @default.
- W2615202319 title "C1q/TNF-related protein 9 inhibits the cholesterol-induced Vascular smooth muscle cell phenotype switch and cell dysfunction by activating AMP-dependent kinase" @default.
- W2615202319 cites W1534433422 @default.
- W2615202319 cites W1796334439 @default.
- W2615202319 cites W1799271499 @default.
- W2615202319 cites W1824297940 @default.
- W2615202319 cites W1921371649 @default.
- W2615202319 cites W1947083548 @default.
- W2615202319 cites W1968876618 @default.
- W2615202319 cites W1969736091 @default.
- W2615202319 cites W1970205234 @default.
- W2615202319 cites W1972974430 @default.
- W2615202319 cites W1974762968 @default.
- W2615202319 cites W1979956597 @default.
- W2615202319 cites W1982092265 @default.
- W2615202319 cites W1982872296 @default.
- W2615202319 cites W1983874326 @default.
- W2615202319 cites W2017262317 @default.
- W2615202319 cites W2029718896 @default.
- W2615202319 cites W2033896075 @default.
- W2615202319 cites W2034334928 @default.
- W2615202319 cites W2035192731 @default.
- W2615202319 cites W2064746492 @default.
- W2615202319 cites W2076571657 @default.
- W2615202319 cites W2090821845 @default.
- W2615202319 cites W2096194215 @default.
- W2615202319 cites W2112103567 @default.
- W2615202319 cites W2115593266 @default.
- W2615202319 cites W2116187812 @default.
- W2615202319 cites W2122394887 @default.
- W2615202319 cites W2124376174 @default.
- W2615202319 cites W2126712214 @default.
- W2615202319 cites W2138463356 @default.
- W2615202319 cites W2141814949 @default.
- W2615202319 cites W2145303423 @default.
- W2615202319 cites W2154947798 @default.
- W2615202319 cites W2157280773 @default.
- W2615202319 cites W2161682643 @default.
- W2615202319 cites W2165660930 @default.
- W2615202319 cites W2175680864 @default.
- W2615202319 cites W2204491745 @default.
- W2615202319 cites W2222665820 @default.
- W2615202319 cites W2302528395 @default.
- W2615202319 cites W2317067038 @default.
- W2615202319 cites W2397457820 @default.
- W2615202319 cites W2419293200 @default.
- W2615202319 cites W2462368809 @default.
- W2615202319 cites W2475030461 @default.
- W2615202319 cites W2495036841 @default.
- W2615202319 cites W2527909544 @default.
- W2615202319 cites W2530382325 @default.
- W2615202319 cites W2553190944 @default.
- W2615202319 cites W2556760519 @default.
- W2615202319 doi "https://doi.org/10.1111/jcmm.13196" @default.
- W2615202319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5661105" @default.
- W2615202319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28524645" @default.
- W2615202319 hasPublicationYear "2017" @default.
- W2615202319 type Work @default.
- W2615202319 sameAs 2615202319 @default.
- W2615202319 citedByCount "29" @default.
- W2615202319 countsByYear W26152023192018 @default.
- W2615202319 countsByYear W26152023192019 @default.
- W2615202319 countsByYear W26152023192020 @default.
- W2615202319 countsByYear W26152023192021 @default.
- W2615202319 countsByYear W26152023192022 @default.
- W2615202319 countsByYear W26152023192023 @default.
- W2615202319 crossrefType "journal-article" @default.
- W2615202319 hasAuthorship W2615202319A5018728349 @default.
- W2615202319 hasAuthorship W2615202319A5029579774 @default.
- W2615202319 hasAuthorship W2615202319A5049043613 @default.
- W2615202319 hasAuthorship W2615202319A5051221401 @default.
- W2615202319 hasAuthorship W2615202319A5059314796 @default.
- W2615202319 hasAuthorship W2615202319A5059712495 @default.
- W2615202319 hasAuthorship W2615202319A5071037763 @default.
- W2615202319 hasAuthorship W2615202319A5078135774 @default.
- W2615202319 hasAuthorship W2615202319A5078863108 @default.
- W2615202319 hasAuthorship W2615202319A5085028455 @default.
- W2615202319 hasBestOaLocation W26152023191 @default.
- W2615202319 hasConcept C104317684 @default.
- W2615202319 hasConcept C110459506 @default.
- W2615202319 hasConcept C126322002 @default.
- W2615202319 hasConcept C127561419 @default.
- W2615202319 hasConcept C134018914 @default.
- W2615202319 hasConcept C149011108 @default.
- W2615202319 hasConcept C17991360 @default.