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- W2615221204 endingPage "6623" @default.
- W2615221204 startingPage "6609" @default.
- W2615221204 abstract "Nine bis(thiosemicarbazone) (BTSC) cobalt(III) complexes of the general formula [Co(BTSC)(L)2]NO3 were synthesized, where BTSC = diacetyl bis(thiosemicarbazone) (ATS), pyruvaldehyde bis(thiosemicarbazone) (PTS), or glyoxal bis(thiosemicarbazone) (GTS) and L = ammonia, imidazole (Im), or benzylamine (BnA). These compounds were characterized by multinuclear NMR spectroscopy, mass spectrometry, cyclic voltammetry, and X-ray crystallography. Their stability in phosphate-buffered saline was investigated and found to be highly dependent on the nature of the axial ligand, L. These studies revealed that complex stability is primarily dictated by the axial ligand following the sequence NH3 > Im > BnA. The cellular uptake and cytotoxicity in cancer cells were also determined. Both the cellular uptake and cytotoxicity were significantly affected by the nature of the equatorial BTSC. Complexes of ATS were taken up much more effectively than those of PTS and GTS. The cytotoxicity of the complexes was correlated to that of the free ligand. Cell uptake and cytotoxicity were also determined under hypoxic conditions. Only minor differences in the hypoxia activity and uptake were observed. Treatment of the cancer cells with the copper-depleting agent tetrathiomolybdate decreased the cytotoxic potency of the complexes, indicating that they may operate via a copper-dependent mechanism. These results provide a structure–activity relationship for this class of compounds, which may be applied for the rational design of new cobalt(III) anticancer agents." @default.
- W2615221204 created "2017-05-26" @default.
- W2615221204 creator A5013212578 @default.
- W2615221204 creator A5038368495 @default.
- W2615221204 creator A5046662341 @default.
- W2615221204 creator A5054833028 @default.
- W2615221204 creator A5072090625 @default.
- W2615221204 date "2017-05-16" @default.
- W2615221204 modified "2023-10-16" @default.
- W2615221204 title "Bis(thiosemicarbazone) Complexes of Cobalt(III). Synthesis, Characterization, and Anticancer Potential" @default.
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- W2615221204 doi "https://doi.org/10.1021/acs.inorgchem.7b00710" @default.
- W2615221204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8113979" @default.