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- W2615229417 abstract "Disproportionately elevated fasting levels of proinsulin immunoreactive material (PIM)relative to insulin immunoreactivity (IRI) are a well-established abnormality in type 2 diabetes. Thesignificance of this abnormality has been investigated and discussed in several studies. Areas covered: The present review focuses on the role of proinsulin and its conversion intermediates inthe development of type 2 diabetes, obesity and insulin resistance, and the potential role as a marker ofcardiovascular risk, including the most important studies in this field. Expert commentary: The composition of plasma PIM is heterogeneous comprising des(31,32)-proinsulin,intact proinsulin and small amounts of des(64,65)-proinsulin. Disproportionate hyperproinsulinemiaseems to occur early in the development and before the diagnosis of type 2 diabetes, and seemsassociated to disease progression. Obesity and insulin resistance does not influence fasting PIM/IRI levels in type 2 diabetes. Fasting PIM/IRI levels in type 2 diabetes are closely associated with the degree of impairment in insulin secretory capacity. Different type 2 diabetes alleles have been described associated with elevated PIM/IRI levels. Recent data suggests that proinsulin and its conversion intermediates may have a role as markers of increased risk of cardiovascular disease in glucose intolerance and type 2 diabetes." @default.
- W2615229417 created "2017-05-26" @default.
- W2615229417 creator A5031363132 @default.
- W2615229417 date "2017-05-29" @default.
- W2615229417 modified "2023-10-16" @default.
- W2615229417 title "Hyperproinsulinemia in obesity and in type 2 diabetes and its relation to cardiovascular disease" @default.
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- W2615229417 doi "https://doi.org/10.1080/17446651.2017.1331735" @default.
- W2615229417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30058886" @default.
- W2615229417 hasPublicationYear "2017" @default.
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