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• W2615260520 abstract "3-Hydroxypropionic acid (3-HP) can be converted into derivatives such as acrylic acid, a source for producing super absorbent polymers. Although Escherichia coli has often been used for 3-HP production, it exhibits low tolerance to 3-HP. To circumvent this problem, we selected the fission yeast Schizosaccharomyces pombe as this microorganism has higher tolerance to 3-HP than E. coli. Therefore, we constructed S. pombe transformants overexpressing two genes, one encoding the S. pombe acetyl-CoA carboxylase (Cut6p) and the other encoding the malonyl-CoA reductase derived from Chloroflexus aurantiacus (CaMCR). To prevent the degradation of these expressed proteins, we employed an S. pombe protease-deficient strain. Moreover, to increase the cytosolic concentration of acetyl-CoA, we supplemented acetate to the medium, which improved 3-HP production. To further produce 3-HP by overexpressing Cut6p and CaMCR, we exploited the highly expressing S. pombe hsp9 promoter. Finally, culturing in high-density reached 3-HP production to 7.6 g/L at 31 h." @default.
• W2615260520 created "2017-05-26" @default.
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• W2615260520 date "2017-10-01" @default.
• W2615260520 modified "2023-09-24" @default.
• W2615260520 title "Production of 3-hydroxypropionic acid via the malonyl-CoA pathway using recombinant fission yeast strains" @default.
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• W2615260520 doi "https://doi.org/10.1016/j.jbiosc.2017.04.015" @default.
• W2615260520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28522285" @default.
• W2615260520 hasPublicationYear "2017" @default.
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