FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615324933> ?p ?o ?g. }

• W2615324933 abstract "Tumor cell transplantation is an important technique to define the mechanisms controlling cancer cell growth, migration, and host response, as well as to assess potential patient response to therapy. Current methods largely depend on using syngeneic or immune-compromised animals to avoid rejection of the tumor graft. Such methods require the use of specific genetic strains that often prevent the analysis of immune-tumor cell interactions and/or are limited to specific genetic backgrounds. An alternative method in zebrafish takes advantage of an incompletely developed immune system in the embryonic brain before 3 days, where tumor cells are transplanted for use in short-term assays (i.e., 3 to 10 days). However, these methods cause host lethality, which prevents the long-term study of tumor cell behavior and drug response. This protocol describes a simple and efficient method for the long-term orthotopic transplantation of zebrafish brain tumor tissue into the fourth ventricle of a 2-day-old immune-competent zebrafish. This method allows: 1) long-term study of tumor cell behaviors, such as invasion and dissemination; 2) durable tumor response to drugs; and 3) re-transplantation of tumors for the study of tumor evolution and/or the impact of different host genetic backgrounds. In summary, this technique allows cancer researchers to assess engraftment, invasion, and growth at distant sites, as well as to perform chemical screens and cell competition assays over many months. This protocol can be extended to studies of other tumor types and can be used to elucidate mechanisms of chemoresistance and metastasis." @default.
• W2615324933 created "2017-05-26" @default.
• W2615324933 creator A5017847712 @default.
• W2615324933 creator A5023904208 @default.
• W2615324933 creator A5038705503 @default.
• W2615324933 creator A5065745446 @default.
• W2615324933 creator A5069401265 @default.
• W2615324933 creator A5072552231 @default.
• W2615324933 creator A5077218621 @default.
• W2615324933 creator A5083813412 @default.
• W2615324933 date "2017-05-17" @default.
• W2615324933 modified "2023-09-29" @default.
• W2615324933 title "Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response" @default.
• W2615324933 cites W141939968 @default.
• W2615324933 cites W1441596392 @default.
• W2615324933 cites W1552182593 @default.
• W2615324933 cites W1560414645 @default.
• W2615324933 cites W1596814296 @default.
• W2615324933 cites W1956119335 @default.
• W2615324933 cites W1967241654 @default.
• W2615324933 cites W1971571835 @default.
• W2615324933 cites W1972896709 @default.
• W2615324933 cites W1976185346 @default.
• W2615324933 cites W1980642761 @default.
• W2615324933 cites W1981239255 @default.
• W2615324933 cites W1992252639 @default.
• W2615324933 cites W1996816592 @default.
• W2615324933 cites W1997455874 @default.
• W2615324933 cites W2001740805 @default.
• W2615324933 cites W2003007609 @default.
• W2615324933 cites W2006989757 @default.
• W2615324933 cites W2019751519 @default.
• W2615324933 cites W2023440330 @default.
• W2615324933 cites W2034933577 @default.
• W2615324933 cites W2038082544 @default.
• W2615324933 cites W2046673025 @default.
• W2615324933 cites W2051239163 @default.
• W2615324933 cites W2054972714 @default.
• W2615324933 cites W2059554984 @default.
• W2615324933 cites W2066170225 @default.
• W2615324933 cites W2068461857 @default.
• W2615324933 cites W2073971491 @default.
• W2615324933 cites W2075986393 @default.
• W2615324933 cites W2090453278 @default.
• W2615324933 cites W2103339723 @default.
• W2615324933 cites W2108333200 @default.
• W2615324933 cites W2111039767 @default.
• W2615324933 cites W2115474273 @default.
• W2615324933 cites W2117075401 @default.
• W2615324933 cites W2117692326 @default.
• W2615324933 cites W2120191503 @default.
• W2615324933 cites W2121676856 @default.
• W2615324933 cites W2128171790 @default.
• W2615324933 cites W2134433047 @default.
• W2615324933 cites W2135180720 @default.
• W2615324933 cites W2143263348 @default.
• W2615324933 cites W2146715702 @default.
• W2615324933 cites W2153649171 @default.
• W2615324933 cites W2161504438 @default.
• W2615324933 cites W2167240068 @default.
• W2615324933 cites W2170366279 @default.
• W2615324933 cites W2225252862 @default.
• W2615324933 cites W2283867249 @default.
• W2615324933 cites W2465761834 @default.
• W2615324933 cites W2526123185 @default.
• W2615324933 cites W2536549051 @default.
• W2615324933 cites W4237101909 @default.
• W2615324933 cites W4239608233 @default.
• W2615324933 doi "https://doi.org/10.3791/55712" @default.
• W2615324933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5607995" @default.
• W2615324933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28570545" @default.
• W2615324933 hasPublicationYear "2017" @default.
• W2615324933 type Work @default.
• W2615324933 sameAs 2615324933 @default.
• W2615324933 citedByCount "13" @default.
• W2615324933 countsByYear W26153249332017 @default.
• W2615324933 countsByYear W26153249332018 @default.
• W2615324933 countsByYear W26153249332020 @default.
• W2615324933 countsByYear W26153249332021 @default.
• W2615324933 countsByYear W26153249332022 @default.
• W2615324933 countsByYear W26153249332023 @default.
• W2615324933 crossrefType "journal-article" @default.
• W2615324933 hasAuthorship W2615324933A5017847712 @default.
• W2615324933 hasAuthorship W2615324933A5023904208 @default.
• W2615324933 hasAuthorship W2615324933A5038705503 @default.
• W2615324933 hasAuthorship W2615324933A5065745446 @default.
• W2615324933 hasAuthorship W2615324933A5069401265 @default.
• W2615324933 hasAuthorship W2615324933A5072552231 @default.
• W2615324933 hasAuthorship W2615324933A5077218621 @default.
• W2615324933 hasAuthorship W2615324933A5083813412 @default.
• W2615324933 hasBestOaLocation W26153249331 @default.
• W2615324933 hasConcept C104317684 @default.
• W2615324933 hasConcept C121608353 @default.
• W2615324933 hasConcept C126322002 @default.
• W2615324933 hasConcept C142724271 @default.
• W2615324933 hasConcept C145103041 @default.
• W2615324933 hasConcept C1491633281 @default.
• W2615324933 hasConcept C203014093 @default.
• W2615324933 hasConcept C2776878037 @default.
• W2615324933 hasConcept C2779013556 @default.

• next