FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615390224> ?p ?o ?g. }

• W2615390224 endingPage "1038" @default.
• W2615390224 startingPage "1032" @default.
• W2615390224 abstract "Objective. Systemic lupus erythematosus (SLE) is associated with an increased risk of cardiovascular disease (CVD). Thromboprophylaxis with low-dose aspirin (ASA) and hydroxychloroquine (HCQ) seems promising in SLE. We investigated the effects of HCQ cumulative dosages (c-HCQ) and the possible synergistic efficacy of ASA and HCQ in preventing a first CV event (CVE) in patients with SLE. Methods. Patients consecutively admitted to our center who, at admission, satisfied the 1997 American College of Rheumatology and/or 2012 Systemic Lupus Collaborating Clinics classification criteria for SLE, and had not experienced any CVE, were enrolled. The occurrence of a thrombotic event, use of ASA, and c-HCQ were recorded. Kaplan-Meier analysis was performed to determine the c-HCQ associated with a lower incidence of CVE. Cox regression analysis served to identify factors associated with a first CVE. Results. For the study, 189 patients with SLE were enrolled and monitored for 13 years (median). Ten CVE occurred during followup. At Kaplan-Meier analysis, the CVE-free rate was higher in ASA-treated patients administered a c-HCQ > 600 g (standard HCQ dose for at least 5 yrs) than in patients receiving ASA alone, or with a c-HCQ dose < 600 g (log-rank test chi-square = 4.01, p = 0.04). Multivariate analysis showed that antimalarials plus ASA protected against thrombosis (HR 0.041 and HR 0.047, respectively), while antiphospholipid antibodies (HR 17.965) and hypertension (HR 18.054) increased the risk of a first CVE. Conclusion. Our results suggest that prolonged use of HCQ plus ASA is thromboprotective in SLE and provides additional evidence for its continued use in patients with SLE." @default.
• W2615390224 created "2017-05-26" @default.
• W2615390224 creator A5008999067 @default.
• W2615390224 creator A5014482226 @default.
• W2615390224 creator A5017193311 @default.
• W2615390224 creator A5028651643 @default.
• W2615390224 creator A5065011627 @default.
• W2615390224 date "2017-05-15" @default.
• W2615390224 modified "2023-10-14" @default.
• W2615390224 title "Longterm Hydroxychloroquine Therapy and Low-dose Aspirin May Have an Additive Effectiveness in the Primary Prevention of Cardiovascular Events in Patients with Systemic Lupus Erythematosus" @default.
• W2615390224 cites W1820454135 @default.
• W2615390224 cites W1963756694 @default.
• W2615390224 cites W1964598562 @default.
• W2615390224 cites W1985153254 @default.
• W2615390224 cites W2010633868 @default.
• W2615390224 cites W2014873778 @default.
• W2615390224 cites W2022911567 @default.
• W2615390224 cites W2024228574 @default.
• W2615390224 cites W2026467105 @default.
• W2615390224 cites W2037108451 @default.
• W2615390224 cites W2044410409 @default.
• W2615390224 cites W2050117403 @default.
• W2615390224 cites W2052413901 @default.
• W2615390224 cites W2070527591 @default.
• W2615390224 cites W2077806147 @default.
• W2615390224 cites W2103025454 @default.
• W2615390224 cites W2105798455 @default.
• W2615390224 cites W2108905161 @default.
• W2615390224 cites W2113864921 @default.
• W2615390224 cites W2114440931 @default.
• W2615390224 cites W2118914856 @default.
• W2615390224 cites W2132053014 @default.
• W2615390224 cites W2156097706 @default.
• W2615390224 cites W2157038471 @default.
• W2615390224 cites W2159860161 @default.
• W2615390224 cites W2162982134 @default.
• W2615390224 cites W2165779517 @default.
• W2615390224 cites W2165897466 @default.
• W2615390224 cites W2225742804 @default.
• W2615390224 cites W2409726716 @default.
• W2615390224 cites W4242308600 @default.
• W2615390224 doi "https://doi.org/10.3899/jrheum.161351" @default.
• W2615390224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28507183" @default.
• W2615390224 hasPublicationYear "2017" @default.
• W2615390224 type Work @default.
• W2615390224 sameAs 2615390224 @default.
• W2615390224 citedByCount "71" @default.
• W2615390224 countsByYear W26153902242018 @default.
• W2615390224 countsByYear W26153902242019 @default.
• W2615390224 countsByYear W26153902242020 @default.
• W2615390224 countsByYear W26153902242021 @default.
• W2615390224 countsByYear W26153902242022 @default.
• W2615390224 countsByYear W26153902242023 @default.
• W2615390224 crossrefType "journal-article" @default.
• W2615390224 hasAuthorship W2615390224A5008999067 @default.
• W2615390224 hasAuthorship W2615390224A5014482226 @default.
• W2615390224 hasAuthorship W2615390224A5017193311 @default.
• W2615390224 hasAuthorship W2615390224A5028651643 @default.
• W2615390224 hasAuthorship W2615390224A5065011627 @default.
• W2615390224 hasConcept C120665830 @default.
• W2615390224 hasConcept C121332964 @default.
• W2615390224 hasConcept C126322002 @default.
• W2615390224 hasConcept C198451711 @default.
• W2615390224 hasConcept C2776874634 @default.
• W2615390224 hasConcept C2776912625 @default.
• W2615390224 hasConcept C2777628954 @default.
• W2615390224 hasConcept C2779123688 @default.
• W2615390224 hasConcept C2779134260 @default.
• W2615390224 hasConcept C2780868729 @default.
• W2615390224 hasConcept C3008058167 @default.
• W2615390224 hasConcept C50382708 @default.
• W2615390224 hasConcept C524204448 @default.
• W2615390224 hasConcept C61511704 @default.
• W2615390224 hasConcept C71924100 @default.
• W2615390224 hasConcept C90924648 @default.
• W2615390224 hasConceptScore W2615390224C120665830 @default.
• W2615390224 hasConceptScore W2615390224C121332964 @default.
• W2615390224 hasConceptScore W2615390224C126322002 @default.
• W2615390224 hasConceptScore W2615390224C198451711 @default.
• W2615390224 hasConceptScore W2615390224C2776874634 @default.
• W2615390224 hasConceptScore W2615390224C2776912625 @default.
• W2615390224 hasConceptScore W2615390224C2777628954 @default.
• W2615390224 hasConceptScore W2615390224C2779123688 @default.
• W2615390224 hasConceptScore W2615390224C2779134260 @default.
• W2615390224 hasConceptScore W2615390224C2780868729 @default.
• W2615390224 hasConceptScore W2615390224C3008058167 @default.
• W2615390224 hasConceptScore W2615390224C50382708 @default.
• W2615390224 hasConceptScore W2615390224C524204448 @default.
• W2615390224 hasConceptScore W2615390224C61511704 @default.
• W2615390224 hasConceptScore W2615390224C71924100 @default.
• W2615390224 hasConceptScore W2615390224C90924648 @default.
• W2615390224 hasIssue "7" @default.
• W2615390224 hasLocation W26153902241 @default.
• W2615390224 hasLocation W26153902242 @default.
• W2615390224 hasOpenAccess W2615390224 @default.
• W2615390224 hasPrimaryLocation W26153902241 @default.
• W2615390224 hasRelatedWork W2017275815 @default.
• W2615390224 hasRelatedWork W2068265433 @default.

• next