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- W2615397340 abstract "The prognostic importance of specific and general tests of immune function were examined among a cohort of 170 subjects infected with human immunodeficiency virus type-1 (HIV), living in an area endemic for the fungal infection coccidioidomycosis. Using the proportional hazards model and multivariate analysis, lack of expression of coccidioidal delayed-type hypersensitivity (DTH) was found to be dependent on anergy in response to the non-coccidioidal antigens mumps, Trichophyton and Candida (relative hazard 4·2, 95% CI 1·8–9·8, P=0·001). Among subjects with CD4 lymphocyte counts ≥250 μl−1 on entry into the study, the in vitro lymphocyte transformation (LT) response to the coccidioidal antigen toluene spherule lysate was 4967±1652 (mean counts per minute (c.p.m.)±SEM) in subjects with coccidioidal DTH compared with 136±222 in those with negative DTH (P<0·001). However, amongst those whose CD4 count was <250 μl−1, LT responses were low and there was no significant difference based on coccidioidal DTH (P=0·965). Using the proportional hazards model and multivariate analysis, only a CD4 count <250 μl−1 was prognostically associated with the development of either active coccidioidomycosis or AIDS. These data indicate that immunodeficiency, particularly a CD4 lymphocyte count <250 μl−1, is the most important factor in the lack of expression of specific immunity to coccidioidomycosis and in the development of active coccidioidomycosis among HIV-infected individuals living in the coccidioidal endemic area." @default.
- W2615397340 created "2017-05-26" @default.
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- W2615397340 date "2008-07-18" @default.
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- W2615397340 title "Delayed-type hypersensitivity, in vitro T-cell responsiveness and risk of active coccidioidomycosis among HIV-infected patients living in the coccidioidal endemic area" @default.
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- W2615397340 doi "https://doi.org/10.1111/j.1365-280x.1999.00227.x" @default.
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