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- W2615538013 endingPage "1401" @default.
- W2615538013 startingPage "1391" @default.
- W2615538013 abstract "RNA interference (RNAi) is emerging as a powerful approach in cancer treatment. siRNA is an important RNAi tool that can be designed to specifically silence the expression of genes involved in drug resistance and chemotherapeutic inactivity. Combining siRNA and other therapeutic agents can overcome the multidrug resistance (MDR) phenomenon by simultaneously silencing genes and enhancing chemotherapeutic activity. Moreover, the therapeutic efficiency of anticancer drugs can be significantly improved by additive or synergistic effects induced by siRNA and combined therapies. Co-delivery of these diverse anticancer agents, however, requires specially designed nanocarriers. This review highlights the recent trends in siRNA/anticancer drug co-delivery systems under the major categories of liposomes/lipid, polymeric and inorganic nanoplatforms. The objective is to discuss the strategies for nanocarrier-based co-delivery systems using siRNA/anticancer drug combinations, emphasizing various siRNA targets that help overcome MDR and enhance therapeutic efficiency." @default.
- W2615538013 created "2017-05-26" @default.
- W2615538013 creator A5061541712 @default.
- W2615538013 creator A5068736204 @default.
- W2615538013 creator A5085523826 @default.
- W2615538013 date "2017-05-19" @default.
- W2615538013 modified "2023-10-16" @default.
- W2615538013 title "Combinatorial therapeutic approaches with RNAi and anticancer drugs using nanodrug delivery systems" @default.
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