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- W2615538848 abstract "Hybrid aerogels of chitosan (CS), carboxymethyl cellulose (CMC) and graphene oxide (GO) are successfully prepared by using calcium ion (Ca2+) as the crosslinker. The resultant hybrid aerogels, CS/CMC/Ca2+/GO, are characterized by field emission scanning electron microscopy (FESEM) and Fourier transform infrared (FT-IR) spectroscopy. Due to the pH sensitivity of CS and CMC, pH-controlled drug delivery with CS/CMC/Ca2+/GO as the carrier is investigated using 5-fluorouracil (5-FU), an effective chemotherapeutic agent in the treatment of cancers, as the model drug. Finally, Higuchi model and Korsmeyer-Peppas model are used to study the release kinetics, and it reveals that the release of 5-FU from the hybrid aerogels is controlled by Fickian diffusion. Collectively, the findings demonstrate the CS/CMC/Ca2+/GO would be a potential material for the construction of pH-controlled drug delivery platform." @default.
- W2615538848 created "2017-05-26" @default.
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- W2615538848 date "2017-10-01" @default.
- W2615538848 modified "2023-10-17" @default.
- W2615538848 title "pH-Controlled drug delivery with hybrid aerogel of chitosan, carboxymethyl cellulose and graphene oxide as the carrier" @default.
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- W2615538848 doi "https://doi.org/10.1016/j.ijbiomac.2017.05.064" @default.
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