Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615662051> ?p ?o ?g. }
- W2615662051 endingPage "1700033" @default.
- W2615662051 startingPage "1700033" @default.
- W2615662051 abstract "Duck Tembusu virus (DTMUV) is a newly emerging pathogenic flavivirus that has caused huge economic losses to the duck industry in China since 2010. Moreover, the infection has spread rapidly, posing a potential public health concern. In this study, iTRAQ approach was first used to quantitatively identify differentially expressed cellular proteins in DTMUV-infected BHK-21 cells which are usually employed to produce veterinary vaccines for DTMUV, as well as other flaviviruses by serial passage. We identified 192 differentially expressed cellular proteins, including 11 upregulated and eight downregulated proteins at 24 h postinfection (hpi), as well as 25 upregulated and 151 downregulated proteins at 48 hpi, of which TLR9, DDX3X, and DDX5 may play important roles in virus propagation. Further, DDX3X could inhibit DTMUV replication by modulating the IFN pathway via TBK1. In conclusion, our study is the first to analyze the protein profile of DTMUV-infected cells by quantitative proteomics. We believe that our findings provide valuable information in better understanding the host response to DTMUV infection. These findings are particularly important in the development of vaccine-based strategies." @default.
- W2615662051 created "2017-05-26" @default.
- W2615662051 creator A5027030295 @default.
- W2615662051 creator A5033829858 @default.
- W2615662051 creator A5045575548 @default.
- W2615662051 creator A5057007670 @default.
- W2615662051 creator A5061543326 @default.
- W2615662051 creator A5061834037 @default.
- W2615662051 creator A5074707535 @default.
- W2615662051 creator A5076707975 @default.
- W2615662051 creator A5086559201 @default.
- W2615662051 date "2017-06-01" @default.
- W2615662051 modified "2023-10-16" @default.
- W2615662051 title "Proteome analysis of Duck Tembusu virus (DTMUV)-infected BHK-21 cells" @default.
- W2615662051 cites W1439881950 @default.
- W2615662051 cites W1490516138 @default.
- W2615662051 cites W1529133069 @default.
- W2615662051 cites W1893895415 @default.
- W2615662051 cites W1930368175 @default.
- W2615662051 cites W1963981879 @default.
- W2615662051 cites W1967269679 @default.
- W2615662051 cites W1968194809 @default.
- W2615662051 cites W1976262374 @default.
- W2615662051 cites W1983124094 @default.
- W2615662051 cites W1989849546 @default.
- W2615662051 cites W1990521726 @default.
- W2615662051 cites W2001100529 @default.
- W2615662051 cites W2002779668 @default.
- W2615662051 cites W2003760082 @default.
- W2615662051 cites W2004773897 @default.
- W2615662051 cites W2006427830 @default.
- W2615662051 cites W2013056595 @default.
- W2615662051 cites W2023309048 @default.
- W2615662051 cites W2025421304 @default.
- W2615662051 cites W2030428409 @default.
- W2615662051 cites W2032730860 @default.
- W2615662051 cites W2037199116 @default.
- W2615662051 cites W2040308254 @default.
- W2615662051 cites W2042819794 @default.
- W2615662051 cites W2045163535 @default.
- W2615662051 cites W2052004319 @default.
- W2615662051 cites W2056957860 @default.
- W2615662051 cites W2065959827 @default.
- W2615662051 cites W2069367707 @default.
- W2615662051 cites W2069772801 @default.
- W2615662051 cites W2077185255 @default.
- W2615662051 cites W2078188527 @default.
- W2615662051 cites W2078811876 @default.
- W2615662051 cites W2086902802 @default.
- W2615662051 cites W2088835085 @default.
- W2615662051 cites W2092110803 @default.
- W2615662051 cites W2107276107 @default.
- W2615662051 cites W2113241472 @default.
- W2615662051 cites W2114741192 @default.
- W2615662051 cites W2115129497 @default.
- W2615662051 cites W2119638322 @default.
- W2615662051 cites W2127908895 @default.
- W2615662051 cites W2129976921 @default.
- W2615662051 cites W2142961497 @default.
- W2615662051 cites W2154672212 @default.
- W2615662051 cites W2155908452 @default.
- W2615662051 cites W2159737843 @default.
- W2615662051 cites W2163412375 @default.
- W2615662051 cites W2165907695 @default.
- W2615662051 cites W2169711334 @default.
- W2615662051 cites W2187937073 @default.
- W2615662051 cites W2335264887 @default.
- W2615662051 cites W2467633302 @default.
- W2615662051 cites W2474614962 @default.
- W2615662051 cites W4211014298 @default.
- W2615662051 cites W4232534952 @default.
- W2615662051 cites W4234586755 @default.
- W2615662051 cites W4241618705 @default.
- W2615662051 doi "https://doi.org/10.1002/pmic.201700033" @default.
- W2615662051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28516729" @default.
- W2615662051 hasPublicationYear "2017" @default.
- W2615662051 type Work @default.
- W2615662051 sameAs 2615662051 @default.
- W2615662051 citedByCount "13" @default.
- W2615662051 countsByYear W26156620512018 @default.
- W2615662051 countsByYear W26156620512019 @default.
- W2615662051 countsByYear W26156620512020 @default.
- W2615662051 countsByYear W26156620512021 @default.
- W2615662051 countsByYear W26156620512022 @default.
- W2615662051 crossrefType "journal-article" @default.
- W2615662051 hasAuthorship W2615662051A5027030295 @default.
- W2615662051 hasAuthorship W2615662051A5033829858 @default.
- W2615662051 hasAuthorship W2615662051A5045575548 @default.
- W2615662051 hasAuthorship W2615662051A5057007670 @default.
- W2615662051 hasAuthorship W2615662051A5061543326 @default.
- W2615662051 hasAuthorship W2615662051A5061834037 @default.
- W2615662051 hasAuthorship W2615662051A5074707535 @default.
- W2615662051 hasAuthorship W2615662051A5076707975 @default.
- W2615662051 hasAuthorship W2615662051A5086559201 @default.
- W2615662051 hasConcept C104317684 @default.
- W2615662051 hasConcept C104397665 @default.
- W2615662051 hasConcept C127561419 @default.
- W2615662051 hasConcept C159047783 @default.