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W2615672653 abstract "Therapies that inhibit CETP (cholesteryl ester transfer protein) have failed to demonstrate a reduction in risk for coronary heart disease (CHD). Human DNA sequence variants that truncate the CETP gene may provide insight into the efficacy of CETP inhibition.To test whether protein-truncating variants (PTVs) at the CETP gene were associated with plasma lipid levels and CHD.We sequenced the exons of the CETP gene in 58 469 participants from 12 case-control studies (18 817 CHD cases, 39 652 CHD-free controls). We defined PTV as those that lead to a premature stop, disrupt canonical splice sites, or lead to insertions/deletions that shift frame. We also genotyped 1 Japanese-specific PTV in 27561 participants from 3 case-control studies (14 286 CHD cases, 13 275 CHD-free controls). We tested association of CETP PTV carrier status with both plasma lipids and CHD. Among 58 469 participants with CETP gene-sequencing data available, average age was 51.5 years and 43% were women; 1 in 975 participants carried a PTV at the CETP gene. Compared with noncarriers, carriers of PTV at CETP had higher high-density lipoprotein cholesterol (effect size, 22.6 mg/dL; 95% confidence interval, 18-27; P<1.0×10-4), lower low-density lipoprotein cholesterol (-12.2 mg/dL; 95% confidence interval, -23 to -0.98; P=0.033), and lower triglycerides (-6.3%; 95% confidence interval, -12 to -0.22; P=0.043). CETP PTV carrier status was associated with reduced risk for CHD (summary odds ratio, 0.70; 95% confidence interval, 0.54-0.90; P=5.1×10-3).Compared with noncarriers, carriers of PTV at CETP displayed higher high-density lipoprotein cholesterol, lower low-density lipoprotein cholesterol, lower triglycerides, and lower risk for CHD." @default.
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W2615672653 date "2017-06-23" @default.
W2615672653 modified "2023-10-12" @default.
W2615672653 title "Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease" @default.
W2615672653 cites W1499959019 @default.
W2615672653 cites W1520609538 @default.
W2615672653 cites W1851286093 @default.
W2615672653 cites W1947690049 @default.
W2615672653 cites W1985885706 @default.
W2615672653 cites W1990231896 @default.
W2615672653 cites W1995722781 @default.
W2615672653 cites W2006921001 @default.
W2615672653 cites W2017602185 @default.
W2615672653 cites W2025514270 @default.
W2615672653 cites W2030157055 @default.
W2615672653 cites W2033738037 @default.
W2615672653 cites W2043261575 @default.
W2615672653 cites W2048760408 @default.
W2615672653 cites W2050838276 @default.
W2615672653 cites W2067539811 @default.
W2615672653 cites W2084744450 @default.
W2615672653 cites W2086180480 @default.
W2615672653 cites W2090464684 @default.
W2615672653 cites W2098230963 @default.
W2615672653 cites W2104570606 @default.
W2615672653 cites W2116404316 @default.
W2615672653 cites W2118825330 @default.
W2615672653 cites W2120451046 @default.
W2615672653 cites W2122049307 @default.
W2615672653 cites W2134811220 @default.
W2615672653 cites W2134930063 @default.
W2615672653 cites W2145813488 @default.