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• W2615678788 abstract "High-order epistasis-where the effect of a mutation is determined by interactions with two or more other mutations-makes small, but detectable, contributions to genotype-fitness maps. While epistasis between pairs of mutations is known to be an important determinant of evolutionary trajectories, the evolutionary consequences of high-order epistasis remain poorly understood. To determine the effect of high-order epistasis on evolutionary trajectories, we computationally removed high-order epistasis from experimental genotype-fitness maps containing all binary combinations of five mutations. We then compared trajectories through maps both with and without high-order epistasis. We found that high-order epistasis strongly shapes the accessibility and probability of evolutionary trajectories. A closer analysis revealed that the magnitude of epistasis, not its order, predicts is effects on evolutionary trajectories. We further find that high-order epistasis makes it impossible to predict evolutionary trajectories from the individual and paired effects of mutations. We therefore conclude that high-order epistasis profoundly shapes evolutionary trajectories through genotype-fitness maps." @default.
• W2615678788 created "2017-05-26" @default.
• W2615678788 creator A5048475119 @default.
• W2615678788 creator A5056170020 @default.
• W2615678788 date "2017-05-15" @default.
• W2615678788 modified "2023-10-16" @default.
• W2615678788 title "High-order epistasis shapes evolutionary trajectories" @default.
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• W2615678788 doi "https://doi.org/10.1371/journal.pcbi.1005541" @default.
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