Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615696046> ?p ?o ?g. }
- W2615696046 abstract "Obstructive sleep apnea (OSA) can be triggered by reduced tongue muscle tone during sleep. The hypoglossal motor nucleus (HMN) is the source of motor output to the tongue, and is a logical pharmacological target for treatment. Targets in this region exist; drugs able to specifically modulate them do not. To test the feasibility of this approach, we modelled a drug-receptor interaction at the HMN by selectively activating engineered receptors inserted into the HMN. Receptor activation by a systemically administered drug increased tongue muscle activity during sleep. Importantly, tongue muscle activity was increased during both rapid eye movement (REM) and non-REM sleep to near-waking levels. The results of this thesis show that selective activation of a pharmacological target locally expressed at the HMN results in sustained tongue muscle activity throughout sleep. This establishes proof-of-principle for modulating a restricted target at the HMN as a viable strategy for pharmacologically treating OSA.%%%%M.Sc." @default.
- W2615696046 created "2017-05-26" @default.
- W2615696046 creator A5020045328 @default.
- W2615696046 date "2016-11-01" @default.
- W2615696046 modified "2023-09-24" @default.
- W2615696046 title "Activation of a Medullary Respiratory Motor Circuit by Remote Control" @default.
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