FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615706002> ?p ?o ?g. }

• W2615706002 endingPage "218" @default.
• W2615706002 startingPage "211" @default.
• W2615706002 abstract "Inflammation could be described as a physiological response of the body to tissue injury, pathogen invasion, and irritants. During the inflammatory phase, cells of both the innate as well as adaptive immune system are activated and recruited to the site of inflammation. These mediators are downstream targets for the transcription factors; activator protein-1 (AP1), nuclear factor kappa-light-chain-enhancer (NF-κB), signal transducers and activators of transcription factors (STAT1), as well as interferon regulatory factors (IRFs), which control the expression of most immunomodulatory genes. There is a significant increase in active p38 mitogen-activated protein kinase (p38MAK) immediately after lipopolysaccharide (LPS) stimulation, which results in the activation of AP-1 transcription factor and expression of proinflammatory cytokines, IL-12 and IL-23. We studied the novel mechanism of p38 MAPK activation through the formation of a heterotrimeric complex of Protein kinase C delta type (PKCδ), Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP), and p38 proteins. TIRAP serves as an adaptor molecule which brings PKCδ and p38 in close proximity. The complex facilitates the activation of p38MAPK by PKCδ. Therefore, we propose that disruption of the heterotrimeric complex may be a good strategy to dampen the inflammatory response. Structure-based design of small molecules or peptides targetting PKCδ-TIRAP or TIRAP-p38 interfaces would be beneficial for therapy in AP1 mediated inflammatory diseases." @default.
• W2615706002 created "2017-05-26" @default.
• W2615706002 creator A5014537111 @default.
• W2615706002 creator A5028188988 @default.
• W2615706002 creator A5032403601 @default.
• W2615706002 creator A5061075341 @default.
• W2615706002 creator A5065769458 @default.
• W2615706002 creator A5076730381 @default.
• W2615706002 creator A5088074814 @default.
• W2615706002 creator A5089027453 @default.
• W2615706002 creator A5091671782 @default.
• W2615706002 date "2017-07-01" @default.
• W2615706002 modified "2023-09-26" @default.
• W2615706002 title "Heterotrimeric complex of p38 MAPK, PKCδ, and TIRAP is required for AP1 mediated inflammatory response" @default.
• W2615706002 cites W1641228030 @default.
• W2615706002 cites W1911986360 @default.
• W2615706002 cites W1965404249 @default.
• W2615706002 cites W1972304405 @default.
• W2615706002 cites W1989729292 @default.
• W2615706002 cites W1992786601 @default.
• W2615706002 cites W1995017064 @default.
• W2615706002 cites W1995744610 @default.
• W2615706002 cites W2001186853 @default.
• W2615706002 cites W2002303369 @default.
• W2615706002 cites W2004465286 @default.
• W2615706002 cites W2022914311 @default.
• W2615706002 cites W2024303872 @default.
• W2615706002 cites W2024489323 @default.
• W2615706002 cites W2030728145 @default.
• W2615706002 cites W2032731042 @default.
• W2615706002 cites W2033849032 @default.
• W2615706002 cites W2035189746 @default.
• W2615706002 cites W2035503835 @default.
• W2615706002 cites W2037312364 @default.
• W2615706002 cites W2049667551 @default.
• W2615706002 cites W2056445309 @default.
• W2615706002 cites W2057207185 @default.
• W2615706002 cites W2066653136 @default.
• W2615706002 cites W2072410510 @default.
• W2615706002 cites W2090602346 @default.
• W2615706002 cites W2095521702 @default.
• W2615706002 cites W2100714950 @default.
• W2615706002 cites W2103079623 @default.
• W2615706002 cites W2106707432 @default.
• W2615706002 cites W2132822330 @default.
• W2615706002 cites W2134156588 @default.
• W2615706002 cites W2153517367 @default.
• W2615706002 cites W2153983456 @default.
• W2615706002 cites W2163888620 @default.
• W2615706002 cites W2169220662 @default.
• W2615706002 cites W4236842068 @default.
• W2615706002 doi "https://doi.org/10.1016/j.intimp.2017.04.028" @default.
• W2615706002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28528205" @default.
• W2615706002 hasPublicationYear "2017" @default.
• W2615706002 type Work @default.
• W2615706002 sameAs 2615706002 @default.
• W2615706002 citedByCount "11" @default.
• W2615706002 countsByYear W26157060022018 @default.
• W2615706002 countsByYear W26157060022019 @default.
• W2615706002 countsByYear W26157060022020 @default.
• W2615706002 countsByYear W26157060022021 @default.
• W2615706002 countsByYear W26157060022022 @default.
• W2615706002 countsByYear W26157060022023 @default.
• W2615706002 crossrefType "journal-article" @default.
• W2615706002 hasAuthorship W2615706002A5014537111 @default.
• W2615706002 hasAuthorship W2615706002A5028188988 @default.
• W2615706002 hasAuthorship W2615706002A5032403601 @default.
• W2615706002 hasAuthorship W2615706002A5061075341 @default.
• W2615706002 hasAuthorship W2615706002A5065769458 @default.
• W2615706002 hasAuthorship W2615706002A5076730381 @default.
• W2615706002 hasAuthorship W2615706002A5088074814 @default.
• W2615706002 hasAuthorship W2615706002A5089027453 @default.
• W2615706002 hasAuthorship W2615706002A5091671782 @default.
• W2615706002 hasConcept C102280478 @default.
• W2615706002 hasConcept C104317684 @default.
• W2615706002 hasConcept C139407321 @default.
• W2615706002 hasConcept C164027704 @default.
• W2615706002 hasConcept C183786373 @default.
• W2615706002 hasConcept C203014093 @default.
• W2615706002 hasConcept C2776914184 @default.
• W2615706002 hasConcept C51551487 @default.
• W2615706002 hasConcept C55493867 @default.
• W2615706002 hasConcept C57074206 @default.
• W2615706002 hasConcept C62478195 @default.
• W2615706002 hasConcept C80631254 @default.
• W2615706002 hasConcept C86339819 @default.
• W2615706002 hasConcept C86803240 @default.
• W2615706002 hasConcept C95444343 @default.
• W2615706002 hasConceptScore W2615706002C102280478 @default.
• W2615706002 hasConceptScore W2615706002C104317684 @default.
• W2615706002 hasConceptScore W2615706002C139407321 @default.
• W2615706002 hasConceptScore W2615706002C164027704 @default.
• W2615706002 hasConceptScore W2615706002C183786373 @default.
• W2615706002 hasConceptScore W2615706002C203014093 @default.
• W2615706002 hasConceptScore W2615706002C2776914184 @default.
• W2615706002 hasConceptScore W2615706002C51551487 @default.
• W2615706002 hasConceptScore W2615706002C55493867 @default.
• W2615706002 hasConceptScore W2615706002C57074206 @default.

• next