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- W2615706937 abstract "目的观察组蛋白去乙酰化酶抑制剂SAHA对人乳腺癌细胞系MDA-MB-435增殖、凋亡等的作用及其相关分子机制。 方法不同浓度的SAHA作用于MDA-MB-435细胞后，采用MTT、流式细胞分析、Western blot、荧光定量PCR等方法检测细胞增殖、凋亡、周期阻滞情况及相关蛋白及mRNA表达。 结果MTT检测结果表明SAHA可呈剂量依赖性抑制细胞增殖，流式细胞分析发现SAHA可导致2/M期周期阻滞、线粒体膜电位下降、活性氧（ROS）产生并发生早期凋亡。同时，SAHA可下调周期蛋白cyclinB、活化p38-MAPK及JNK，抑制p53的表达且可能不是通过PI3K通路、P38 MAPK通路、ERK1/2通路和NF-κB 、JNK通路起作用。 结论SAHA能抑制MDA-MB-435细胞增殖，诱导其周期阻滞及早期凋亡，活化细胞内相关增殖分子，可作为乳腺癌潜在的候选药物。" @default.
- W2615706937 created "2017-05-26" @default.
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- W2615706937 date "2016-12-25" @default.
- W2615706937 modified "2023-09-23" @default.
- W2615706937 title "组蛋白去乙酰化酶抑制剂SAHA抑制乳腺癌细胞MDA-MB-435增殖及促凋亡的作用机制" @default.
- W2615706937 doi "https://doi.org/10.3971/j.issn.1000-8578.2016.12.003" @default.
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