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• W2615708940 abstract "to analyze the effects of hyaluronic acid of different molecular weights in an experimental model of osteoarthritis in rabbits.forty-four male California rabbits were divided randomly into three groups and underwent resection of the anterior cruciate ligament in his right knee. After three weeks of the surgical procedure began three weekly intra-articular injections of hyaluronic acid native (Polireumin(®))-PR, hyaluronic acid branched chain (Synvisc(®))-S and 0.9% saline-P. All animals were sacrificed after twelve weeks of surgery and tibial plateau infiltrated the knees were dissected. Histological cartilage of the support areas of the tibial plateaus were stained with Alcian Blue pH 1.0, Alcian Blue pH = 2.5 and toluidine blue for research on the amount of proteoglycans. The intensity of staining was quantified on a Zeiss microscope apparatus Imager Z2 MetaSystems and analyzed by software MetaferMsearch.the effect of chondroprotetor hyaluronic acids used in the study was confirmed when compared to the control group, but the comparison made between them, there was no statistically significant difference regarding chondroprotetion.the hyaluronic acids tested had chondroprotective effect, with no statistical difference with regard to the different molecular weights.analisar os efeitos do ácido hialurônico de diferentes pesos moleculares em modelo experimental de osteoartrose em coelhos.foram alojados de modo aleatório 44 coelhos da raça California, machos, em três grupos (PR, S e P) e submetidos a ressecção do ligamento cruzado anterior do joelho direito. Decorridas três semanas do procedimento cirúrgico iniciaram‐se as três injeções intra‐articulares semanais de ácido hialurônico nativo (Polireumin®)‐PR, ácido hialurônico de cadeia ramificada (Synvisc®)‐S e soro fisiológico 0,9%‐P. Todos os animais foram sacrificados após 12 semanas do ato cirúrgico e os platôs tibiais dos joelhos infiltrados foram dissecados. Cortes histológicos da cartilagem das áreas de apoio com maior espessura dos platôs tibiais foram corados com Alcian Blue pH = 1,0, Alcian Blue Ph = 2,5 e Azul de Toluidina para pesquisa da quantidade de proteoglicanos. A intensidade de coloração foi quantificada em um aparelho de microscopia ZeissImager Z2 Metasystems e analisada pelo software MetaferMsearch. A análise estatística consistiu no uso dos testes Kolmorogov–Smirnov, análise de variância (Anova), t de Student e qui‐quadrado. O nível de significância usado foi de 5%.o efeito condroprotetor dos ácidos hialurônicos usados no estudo foi demonstrado quando comparado ao do grupo controle, porém, feita a comparação entre si, não houve diferença estatística quanto à condroproteção.os ácidos hialurônicos testados obtiveram efeito condroprotetor, sem diferença estatística com relação aos diferentes pesos moleculares." @default.
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• W2615708940 date "2014-01-01" @default.
• W2615708940 modified "2023-09-26" @default.
• W2615708940 title "Effect of hyaluronic acids as chondroprotective in experimental model of osteoarthrosis" @default.
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• W2615708940 doi "https://doi.org/10.1016/j.rboe.2014.01.007" @default.
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